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  • Blue light  (4)
  • Coronary artery disease (CAD)  (2)
  • 6-benzyladenine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Circulating endothelin-1 levels in type 2 diabetic patients with ischaemic heart disease (1996)
    Springer
    Acta diabetologica 33 (1996), S. 246-248 
    Details
    ISSN: 1432-5233
    Keywords: Endothelin-1 (Et-1) ; Type 2 diabetes mellitus ; Coronary artery disease (CAD)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate whether circulating endothelin-1 (Et-1) may be related to the increased incidence and severity of ischaemic heart disease in type 2 diabetes mellitus, we compared the concentrations in type 2 diabetic patients and in non-diabetic patients with coronary artery disease (CAD) angiographically documented. Plasma levels of Et-1 were determined in 34 type 2 diabetic patients with CAD (16 with stable angina, 6 with unstable angina, 12 with previous myocardial infarction) and in 19 non-diabetic patients with CAD (4 with stable angina, 5 with unstable angina, 10 with previous myocardial infarction). Fifteen diabetic patients without CAD and 9 healthy volunteers served as control subjects. In the type 2 diabetic patients, the mean Et-1 levels were 3.19±1.61 pmol/l in those with stable angina, 3.58±1.92 pmol/l in those with unstable angina, 4.24±2.53 pmol/l in those with myocardial infarction. These values were not significantly different one another, nor from the values obtained from type 2 diabetic controls (3.64±2.13 pmol/l). In the non-diabetic patients, the mean Et-1 levels were 3.92±0.73 pmol/l in those with stable angina, 4.35±1.67 pmol/l in those with unstable angina, 4.33±1.66 pmol/l in those with myocardial infarction. These values were not significantly different one another, but significantly higher than those obtained from healthy controls (2.07±0.67 pmol/l;P〈0.001). No significant differences were found in Et-1 levels between diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction. In contrast, a statistically significant difference was found in Et-1 levels between diabetic and non-diabetic control subjects (P〈0.05). In conclusion, similar raised concentrations of Et-1 in diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction do not support the hypothesis that higher levels of Et-1 in diabetic patients are responsible for the increased incidence of CAD in diabetes mellitus. However, the raised Et-1 levels found in diabetic patients in the absence of CAD strongly suggest that a generalised endothelial dysfunction, documented in our study by increased levels of Et-1, most probably precedes subsequent cardiovascular diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048552
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Circulating endothelin-1 levels in type 2 diabetic patients with ischaemic heart disease (1996)
    Springer
    Acta diabetologica 33 (1996), S. 246-248 
    Details
    ISSN: 1432-5233
    Keywords: Key words Endothelin-1 (Et-1) ; Type 2 diabetes mellitus ; Coronary artery disease (CAD)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate whether circulating endothelin-1 (Et-1) may be related to the increased incidence and severity of ischaemic heart disease in type 2 diabetes mellitus, we compared the concentrations in type 2 diabetic patients and in non-diabetic patients with coronary artery disease (CAD) angiographically documented. Plasma levels of Et-1 were determined in 34 type 2 diabetic patients with CAD (16 with stable angina, 6 with unstable angina, 12 with previous myocardial infarction) and in 19 non-diabetic patients with CAD (4 with stable angina, 5 with unstable angina, 10 with previous myocardial infarction). Fifteen diabetic patients without CAD and 9 healthy volunteers served as control subjects. In the type 2 diabetic patients, the mean Et-1 levels were 3.19±1.61 pmol/l in those with stable angina, 3.58±1.92 pmol/l in those with unstable angina, 4.24±2.53 pmol/l in those with myocardial infarction. These values were not significantly different one another, nor from the values obtained from type 2 diabetic controls (3.64±2.13 pmol/l). In the non-diabetic patients, the mean Et-1 levels were 3.92±0.73 pmol/l in those with stable angina, 4.35±1.67 pmol/l in those with unstable angina, 4.33±1.66 pmol/l in those with myocardial infarction. These values were not significantly different one another, but significantly higher than those obtained from healthy controls (2.07±0.67 pmol/l; P〈0.001). No significant differences were found in Et-1 levels between diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction. In contrast, a statistically significant difference was found in Et-1 levels between diabetic and non-diabetic control subjects (P〈0.05). In conclusion, similar raised concentrations of Et-1 in diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction do not support the hypothesis that higher levels of Et-1 in diabetic patients are responsible for the increased incidence of CAD in diabetes mellitus. However, the raised Et-1 levels found in diabetic patients in the absence of CAD strongly suggest that a generalised endothelial dysfunction, documented in our study by increased levels of Et-1, most probably precedes subsequent cardiovascular diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048552
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Role of nitrogen in the photoinduction of protoperithecia and carotenoids in Neurospora crassa (1987)
    Springer
    Planta 170 (1987), S. 205-208 
    Details
    ISSN: 1432-2048
    Keywords: Ascomycetes ; Blue light ; Carotenoid ; Light and carotenoid induction ; Light and protoperithecia induction ; Neurospora ; Nitrogen and photoinduction ; Protoperithecium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nitrogen, as KNO3 or NH4NO3, can inhibit the photoinduction of protoperithecia in Neurospora crassa when present in the medium at a high concentration but does not inhibit the photoinduction of carotenoids. The point at which the presence of high nitrogen levels is no longer inhibitory is 5 h after illumination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397889
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Are carotenoids the blue-light photoreceptor in the photoinduction of protoperithecia in Neurospora crassa? (1986)
    Springer
    Planta 168 (1986), S. 56-60 
    Details
    ISSN: 1432-2048
    Keywords: Albino mutant ; Ascomycetes ; Carotenoid ; Blue light ; Mutant (Neurospora) ; Neurospora ; Photoreceptor (blue light) ; Protoperithecia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A triple albino mutant of Neurospora crassa with a measured content of carotenoids absorbing at 470 nm less than 0.5% of that of the wild type (calculated value less than 8·10-4%) had the same threshold for photoinduction of protoperithecia as the wild type when illuminated with monochromatic light at 471 nm. This is strong evidence against the hypothesis that the bulk of carotenoids are the blue-light photoreceptor for this phenomenon. However, it is impossible to exclude traces of carotenoids acting as the photoreceptor at less than 3·10-12 M in a very efficient sensory transduction chain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407009
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein in Neurospora crassa (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 223-229 
    Details
    ISSN: 1617-4623
    Keywords: Key words Neurospora crassa ; Blue light ; Mitochondria ; Short-chain alcohol dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Blue light plays an important role in developmental control throughout nature. The bli-4 gene of Neurospora crassa, together with bli-3, al-1 and al-2, is rapidly inducible by blue light. Induction leads to a ninety-fold increase in transcription rate over the dark control level, and the gene therefore appears to be of prime importance in the blue-light induction pathway of N. crassa. We describe the sequencing and analysis of bli-4 and the 38 kDa protein it encodes. We show that the protein is very rapidly imported into the mitochondria and exhibits high homology with the family of short-chain alcohol dehydrogenases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173767
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Mycelial elongation and sporulation of two fungi on amended media in light or dark (1993)
    Springer
    Antonie van Leeuwenhoek 63 (1993), S. 23-27 
    Details
    ISSN: 1572-9699
    Keywords: 6-benzyladenine ; Botrytis allii ; caffeic acid ; chlorogenic acid ; Colletotrichum dematium ; kinetin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Botrytis allii andCollectotrichum dematium are onion pathogens which can infect in the field and cause decay in storage. Some phenolics can hinder development of these fungi, but the effect of cytokinins is not clear. Cytokinins (kinetin or 6-benzyladenine) or phenolics (caffeic or chlorogenic acids) were added to agar at concentrations of 0 to 10−3 M. Cultures were continuously irradiated with fluorescent light or maintained in the dark for 6 days. On unamended media, final mycelial elongation was 45 or 17.8 mm and sporulation was 28 or 10.6 × 104 spores/ml forBotrytis andColletotrichum, respectively. ForBotrytis, mycelial elongation was slightly (5%) but significantly increased and sporulation increased by 21% by incubation on phenolics as compared to cytokinins. Mycelial extension ofColletotrichum was not affected by amendment. Sporulation ofColletotrichum on kinetin was 16 to 28% greater than on the other amendments. As amendments concentration increased elongation of mycelia of both fungi decreased. Sporulation ofBotrytis increased by 60% as amendment concentration increased from 0 to 10−5 M and then decreased 25% at 10−3 M. As amendment concentration increased from 0 to 10−3 M, sporulation ofColletotrichum increased by 45%. Incubation in light increased mycelial extension 3 to 17% forBotrytis andColletotrichum respectively, and sporulation was increased approximately 78% for both fungi. These compounds do not appear to inhibit development of theseBotrytis orColletotrichum species in culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00871727
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein inNeurospora crassa (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 223-229 
    Details
    ISSN: 1617-4623
    Keywords: Neurospora crassa ; Blue light ; Mitochondria ; Short-chain alcohol dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Blue light plays an important role in developmental control throughout nature. Thebli-4 gene ofNeurospora crassa, together withbli-3, al-1 andal-2, is rapidly inducible by blue light. Induction leads to a ninety-fold increase in transcription rate over the dark control level, and the gene therefore appears to be of prime importance in the blue-light induction pathway ofN. crassa. We describe the sequencing and analysis ofbli-4 and the 38 kDa protein it encodes. We show that the protein is very rapidly imported into the mitochondria and exhibits high homology with the family of short-chain alcohol dehydrogenases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173767
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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