ISSN:
1432-2072
Schlagwort(e):
ADTN
;
Nucleus accumbens
;
Ergometrine
;
Dopamine receptors
;
Locomotor stimulants
;
6-hydroxydopamine
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Ergometrine (8 mg/kg) injected intraperitoneally into normal rats had little effect on locomotor activity. In contrast, rats with selective 6-hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens showed a strong stimulation of locomotor activity following injection of this dose of ergometrine. The dopamine analogue 2-amino-6-7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) (150 μg), caused strong and long lasting stimulation of locomotor activity when injected intracerebroventricularly into rats. The ADTN response was markedly reduced in rats with bilateral electrolytic lesions of the nucleus accumbens, but unchanged in rats with bilateral electrolytic lesions of the caudate nucleus. At a lower dose level (50 μg) ADTN, injected intracerebroventricularly, had little effect on the locomotor activity of normal or sham-operated rats. This dose of ADTN was, however, effective in causing locomotor stimulation of rats with bilateral 6-hydroxydopamine-induced lesions of the nucleus accumbens. These results support the view that the dopamine receptors in the nucleus accumbens are involved in the actions of locomotor stimulant drugs.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00735821
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