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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Probability theory and related fields 101 (1995), S. 1-44 
    ISSN: 1432-2064
    Keywords: 60F10 ; 60G57 ; 60K35
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We consider a dynamical interacting particle system whose empirical distribution tends to the solution of a spatially homogeneous Boltzmann type equation, as the number of particles tends to infinity. These laws of large numbers were proved for the Maxwellian molecules by H. Tanaka [Tal] and for the hard spheres by A.S. Sznitman [Szl]. In the present paper we investigate the corresponding large deviations: the large deviation upper bound is obtained and, using convex analysis, a non-variational formulation of the rate function is given. Our results hold for Maxwellian molecules with a cutoff potential and for hard spheres.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1279-8509
    Keywords: Chronic myeloid leukemia ; Additional translocation ; Interferon ; Clonality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a patient with chronic phase CML who exhibited, in the same cells, beside the Philadelphia chromosome, an additional translocation between the other chromosome 9 and one of the chromosomes 12 [t(9;12)(p13;q24.1)]. Complete cytogenetic remission with disappearance of both karyotypic abnormalities was achieved after 18 months treatment with low dose (1.4 × 106 U/m2/day) recombinant alpha-interferon and has been sustained with maintenance therapy for 68+ months (actual follow-up). Clonality at diagnosis and recovery of polyclonal hematopoiesis in complete cytogenetic remission were demonstrated using the polymorphism at the human androgen receptor gene (Humara) locus on chromosome X. The role of the additional translocation in the response to low dose alpha-interferon therapy remains hypothetical.
    Type of Medium: Electronic Resource
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