ISSN:
1432-1440
Keywords:
β-Acetyldigoxin
;
Digitoxin
;
Nifedipine
;
Pharmacokinetics
;
Pharmacodynamics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of nifedipine (N) on the pharmacokinetics and pharmacodynamics of β-acetyldigoxin (AD;n=11) and digitoxin (DGT;n=10) was studied in 21 patients with cardiac insufficiency stage II–III NYHA. Glycoside plasma concentration and renal excretion as well as electrocardiogram heart rate, atrioventricular transconduction time (PQ), duration of electrical systole corrected for heart rate (QTc), mean amplitude of T waves in leads V2 to V6 (TV2−6) and systolic time intervals total electromechanical systole index (QS2I), left ventricular ejection time index (LVETI), pre-ejection period index (PEPI), PEP/LVET-ratio were recorded repeatedly before and during coadministration of 40–60 mg/day N. Plasma AD concentrations were 0.64±0.22 ng/ml (mean±SD) before and 0.61±0.21 ng/ml during co-administration of N over 10–14 days, plasma DGT concentrations 13.9±4.1 ng/ml before and 13.7±4.5 ng/ml during co-administration of N over 4–6 weeks. Daily glycoside excretion was not affected by treatment with N. Heart rate and PQ-interval were not significantly changed during co-administration of N whereas T-wave flattening was intensified and QT-duration was lengthened. Concomitant treatment of AD and N led to an increase of PEPI and PEP/LVET compared to AD alone in ten patients whereas the systolic time intervals after concomitant treatment of DGT and N in most patients did not differ from those after DGT alone. From our findings we conclude that N had no clinically significant effect on pharmacokinetics and pharmacodynamics of AD or DGT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01726906
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