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  • IGF-1  (3)
  • 63.50.+x  (1)
  • 71.25.Cx  (1)
  • Cyclodextrin additives  (1)
  • Gas chromatography  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Global energy spectra of bands and density of states in a class of two-tile systems (1994)
    Springer
    The European physical journal 94 (1994), S. 439-446 
    Details
    ISSN: 1434-6036
    Keywords: 71.25.Cx ; 61.42.+h ; 71.25.-s
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Electronic properties of a general class of one-dimensional two-tile systems are calculated exactly. The systems containing periodic crystals, generalized Fibonacci quasicrystals, generalized Thue-Morse aperiodic lattices and even other two-tile aperiodic lattices, can be divided into two different families which are constructed by the inflation rules: {A, B}→{A m11 B m12,A m21 B m22} and {A, B}→{A n11 B n12,B n21 A n22}, respectively. As typical examples, global spectra of bands and density of states in some two-tile aperiodic systems are numerically calculated. Some interesting properties are obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317406
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of thermal injury on circulating insulin-like growth factor binding proteins in burn patients (1994)
    Springer
    Molecular and cellular biochemistry 135 (1994), S. 171-180 
    Details
    ISSN: 1573-4919
    Keywords: IGF-1 ; IGFBPs ; burn ; serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The results of this report provide evidence that insulin-like growth factor-1 binding proteins (IGFBPs) in human sera are differentially regulated as a result of severe burn injury. Using the ligand binding technique,125I-IGF-1 visualizes 5 different protein bands corresponding to those previously reported for IGFBP-1 to 4 with apparent sizes of 23–42 kd in serum samples prepared from severely burned patients and healthy individuals. The level of IGFBP-3 was significantly decreased within 3–5 days of injury and remained depressed for up to 20 days post injury. The average level of this binding protein reached its lowest value within 3–5 days of the injury (3.8±1.48% relative to day 0–1 value, n=4, p〈0.001). Serum samples from 3 to 4 patients showed no recovery within 20 days post injury and the level of IGFBP-3 remained significantly depressed (p〈0.01). In contrast, the levels of IGFBP-2 and IGFBP-4 increased 2 and 3 fold in the same serum samples within 3–5 days of the burn injury, respectively. This increase returns to normal (day 0–1 value) within 7–10 days for IGFBP-2, but the level of IGFBP-4 remained elevated 4 fold relative to the day 0–1 (p〈0.01). However, the abundance of IGFBP-1 in these serum samples was not significantly altered by the burn injury. By controlling for protein loading, these apparent alterations of IGFBPs in the sera of burned patients were not due to hemodilution. Similarly, significant reductions in IGFBP-3 were not likely due to IGFBP-3 specific protease activity in the sera of burn patients since incubation of sera from burn patients and normal individuals at 37° C did not alter the pattern of IGFBPs in sera obtained from normal individuals. Of interest, the level of IGF-1 protein in these samples was also markedly reduced following severe burn injury similar to IGFBP-3. The results of this study suggest that a marked reduction of serum IGF-1 seen in burn patients is associated with a significant reduction of IGFBP-3, a major IGF-1 binding protein in human serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926520
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  • 3
    Electronic Resource
    Electronic Resource
    Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblasts (1995)
    Springer
    Molecular and cellular biochemistry 148 (1995), S. 25-32 
    Details
    ISSN: 1573-4919
    Keywords: IGF-1 ; burn ; collagen ; hypertrophic scar
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Hypertrophic scarring (HSc) which frequently develops in patients following severe thermal injury is characterized by accumulation of extracellular matrix (ECM) proteins including type I and type III collagen. In this study, we examined the presence and quantity of IGF-1 mRNA transcripts in post-burn HSc. The results of dot blot experiments showed a 77.5% (100±8.15 vs 177.5±19, p〈0.01) increase in expression of IGF-1 IIIRNA in HSc tissue relative to normal dermis obtained from the same patients. A Northern blot analysis confirmed the specificity of the IGF-1 cDNA. This cDNA visualized four different transcripts with apparent sizes of 7.0, 3.9, 1.8 and 1.0 kb, similar to those previously reported. The possible fibrogenic role of IGF-1 was examined by analyzing the effect of this growth factor on the expression of mRNA for the pro α1(I) chain of type I procollagen and the pro α1(III) chain of type III procollagen in dermal fibroblasts. IGF-1 increased the expression of these transcripts as early as 6 h and the effect was maximal at 24 h. Quantitative analysis by densitometry showed a 149 and 166% increase in pro α1(I) and pro α1(III) mRNA after 24 h of IGF-1 treatment, respectively. This effect seems to be specific as the abundance of mRNA for the pro α2(I) chain of type I procollagen or TIMP-II was unchanged. When another 4 strains of dermal fibroblasts were treated with IGF-1, a significant increase (16.94±1.13 vs 10.87±1.79, p〈0.01, N=4) in the expression of type I procollagen mRNA was found. This was consistent with a significant increase in collagen production, as measured by hydroxyproline in conditioned medium (2.04±0.3 ng/1000 cells vs 1.35±0.4 ng/1000 cells, p〈0.01, N=4). The effects of IGF-1 were temporary, since removal of IGF-1 from media caused a reduction in expression of type I procollagen mRNA to its basal level within 48 h. Enhanced expression of IGF-1 mRNA in post-burn HSc tissues and the potentially fibrogenic effects of this growth factor on dermal fibroblasts, suggest that it could contribute to the accumulation of type I and type III collagen found in many fibroproliferative disorders such as HSc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00929499
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  • 4
    Electronic Resource
    Electronic Resource
    Expression and localization of insulin-like growth factor-1 in normal and post-burn hypertrophic scar tissue in human (1998)
    Springer
    Molecular and cellular biochemistry 183 (1998), S. 1-9 
    Details
    ISSN: 1573-4919
    Keywords: IGF-1 ; sweat gland ; skin ; hypertrophic scar ; burn ; fibrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The migration of epithelial cells from dermal appendages toward the wound surface is essential for re-epithelialization of partial thickness burn injuries. This study provides evidence that these cells in vivo synthesize a mitogenic and fibrogenic factor, insulin-like growth factor-1 (IGF-1), which may promote the development of the post-burn fibroproliferative disorder, hypertrophic scarring (HSc). An evaluation of 7 post-burn hypertrophic scars, 7 normal skin samples obtained from the same patients and 4 mature scars revealed that IGF-1 expressing cells from the disrupted sweat glands tend to reform small sweat glands of 4-10 cells/gland in post-burn HSc. The number of these cells increases with time and the glands become larger in mature scar. Other epithelial cells such as those found in sebaceous glands and basal and suprabasal keratinocytes, also express IGF-1 protein and mRNA as detected by Northern and RT-PCR analysis of RNA obtained from whole skin and separated epidermis and dermis. However, cultured keratinocytes did not express mRNA for IGF-1. Histological comparisons between normal and HSc sections show no mature sebaceous glands in dermal fibrotic tissues but the number of IGF-1 producing cells including infiltrated immune cells was markedly higher in the dermis of hypertrophic scar tissues relative to that of the normal control. In these tissues, but not in normal dermis, IGF-1 protein was found associated with the extracellular matrix. By in situ hybridization, IGF-1 mRNA was localized to both epithelial and infiltrated immune cells. Collectively, these findings suggest that in normal skin, fibroblasts have little or no access to diffusible IGF-1 expressed by epithelial cells of the epidermis, sweat and sebaceous glands; while following dermal injury when these structures are disrupted, IGF-1 may contribute to the development of fibrosis through its fibrogenic and mitogenic functions. Reformation of sweat glands during the later stages of healing may, therefore, limit this accessibility, and lead to scar maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006890212478
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  • 5
    Electronic Resource
    Electronic Resource
    An exact renormalization-group approach for local phonon properties of single-atom and double-atom generalized Fibonacci systems (1993)
    Springer
    The European physical journal 91 (1993), S. 467-474 
    Details
    ISSN: 1434-6036
    Keywords: 63.50.+x ; 71.20.Ad ; 61.42+h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present an exact renormalization-group approach to study the local phonon properties of the double-atom generalized Fibonacci systems in which the masses and spring constants are all associated with the aperiodic sequences constructed by the inflation rule: {A, B}→{A n Bm, A}.n(m+1) basic transformations and 2n(n+m−1)+1 basic decimations are introduced. By applying the combinations of derived transformations and decimations, we can determine exactly the renormalized local environment, up to infinite order, of any given site in the double-atom systems. Both the single-atom and double-atom phonon models are employed, and the local density of states in several sites of some generalized Fibonacci systems are numerically calculated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316825
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  • 6
    Electronic Resource
    Electronic Resource
    Study of the chromatographic behavior and inclusion constants of new fluorescence agents by use of cyclodextrin additives under conditions of steady- and dynamic-state equilibrium and with fluorescence detection (1999)
    Springer
    Chromatographia 49 (1999), S. 95-104 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Cyclodextrin additives ; Fluorescence agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary We report four new derivatization agents, acridone-N-acetic acid (ARC), carbazole-9-ylacetic acid (CRA), carbazole-9-ylpropionic acid (CRP), and 2-methyl-2-carbazole-9-ylacetic acid (MCRA), with strong fluorescence emission which has low dependence on solvent polarity. The emission maxima for ARC, CRA, CRP, and MCRA were 430 nm (λex 404 nm), 368 nm (λex 335 nm), 356 nm (λex 340 nm) and 360 nm (λex 330 nm), respectively. The effects of mobile-phase composition, pH, and temperature on the liquid chromatographic retention behavior of the four fluorescence agents were investigated. An experimental model was established for calculating the inclusion constants of cyclodextrin (CD) complexes in the dynamic state, using β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as examples, and different mobilephase compositions. On the basis of the model, the inclusion constants of the solutes in pure water (K fw) were determined by extrapolation. The thermodynamic parameters (ΔH o and ΔS o) and dissociation constantsK am for the solutes in this chromatographic system were obtained by means of capacity factor (k) values using a corresponding model formulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467195
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of organic pollutants in sewage by supercritical fluid extraction (1999)
    Springer
    Chromatographia 49 (1999), S. 399-405 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Solid phase adsorption ; Supercritical fluid extraction ; Sewage ; Organic pollutants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Analytical methods have been developed for the determination of organic pollutants of intermediate polarity in sewage. Water samples are first passed through a solid phase adsorption cartridge. The analytes are then extracted from the absorbent with supercritical CO2 into a small volume of trapping solvent. Finally, the extracts are analyzed directly by capillary gas chromatography and gas chromatography-mass spectrometer. The various parameters (pressure, temperature, type and concentration of modifiers, trapping solvent, flow rate and volume of supercritical fluid and equilibrium time) influencing the efficiency of extraction were studied. Extraction efficiencies for the test compounds are 〉70%, and relative standard deviations are 〈4.6% (n=3). The methods established were applied to the analysis of sewage at the Lanzhou Wastewater Treatment Plant, China. 66 organic pollutants were detected, of which 15 compounds appeared in the list of priority pollutants suggested by the US EPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467613
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