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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computing 57 (1996), S. 255-271 
    ISSN: 1436-5057
    Keywords: 90B35 ; 68M20 ; k-partitioning containing kernels ; NP-complete ; worst case analysis ; LPT-algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Seik≥2 eine natürliche Zahl undG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ eine Menge von höchstenskm nichtnegativen ganzen Zahlen. Gesucht ist eine Partition vonG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ inm Teilmengen, die jeweils nicht mehr alsk Elemente enthalten, sodaß alleg i (Kerne genannt) unterschiedlichen Teilmengen zugeordnet werden und die maximale Summe von Zahlen in einer dieser Teilmengen möglichst klein wird. Wir zeigen zunächst, daß für jedesk≥3 dieses Problem NP-vollständig im starken Sinne ist. Als Heuristik für dieses Problem benutzen wir eine revidierte Version des bekannten LPT-Algorithmus für das Multiprozessorscheduling-Problem. Fürk=3 zeigen wir eine Worst-Case Schranke von 3/2–1/2m.
    Notes: Abstract LetG= $$\{ g_1 ,g_2 , \cdots ,g_m \} \cup \{ t_1 ,t_2 , \cdots ,t_n \} $$ be a list of items with nonnegative weights assigned andk≥2 be an integer. The objective is to find an assignment of the items to the bins such that allg i (called kernels) are assigned to different bins, such that no bin contains more thank items, and such that the maximum weight assigned to any bin becomes minimum. In this paper, we first prove that the problem is NP-complete in the strong sense for anyk≥3. As heuristic for this problem, we use a modified version of the famous LPT-algorithm for multiprocessor scheduling, and we show a worst case bound of 3/2–1/2m fork=3.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Key words Congenital muscular dystrophy ; Walker-Warburg syndrome ; Muscle ; Laminin ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A previous study of two patients with Walker-Warburg syndrome (WWS) showed a severe deficiency of the extracellular matrix protein laminin β2 chain and α-sarcoglycan (adhalin) in skeletal muscle fibers. More recently, however, other researchers have shown that in their WWS patients the expression of the laminin β2 chain and α-sarcoglycan was normal. Here we describe a 1-year-old boy affected with WWS. We performed immunohistochemical studies on a muscle biopsy from this patient using monoclonal antibodies against dystrophin, dystrophin-associated glycoproteins and several proteins of the extracellular matrix. We confirm previously reports as far as the diminished expression of laminin β2 chain and α-sarcoglycan is concerned. The expression of some other laminins was unusual, whereas the expression of collagen IV and VI was normal. These results suggest that complex syndromes like WWS are quite heterogeneous, although they might represent variant expressions of a single pathological entity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Key words Glutamate receptors ; Immunocytochemistry ; Electron microscopy ; Human cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the metabotropic glutamate receptor subunit mGluR1a and the ionotropic glutamate receptor GluR2/3. A small number of non-pyramidal neuronal cell bodies were labelled for mGluR1a. Double immunolabelling with mGluR1a and GluR2/3 showed that most pyramidal cell bodies were labelled for GluR2/3 but not for mGluR1a. Despite the non-colocalisation of these two receptor subtypes in cell bodies, however, many dendrites and dendritic spines were double-labelled for mGluR1a and GluR2/3 at electron microscopy. As there is evidence that most neurons positive for GluR2/3 are pyramidal cells, this suggests that mGluR1a is present in dendrites of pyramidal neurons, despite absent or low levels of immunoreactivity in their cell bodies.
    Type of Medium: Electronic Resource
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