Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 60 (1987), S. 388-393 
    ISSN: 1432-0738
    Keywords: Human lymphoblastoid cells ; Hamster embryo cells ; Pyrimidine excretion ; Toxic response ; Bioassay ; Benzo(a)pyrene ; Diethylstilbestrol ; Nickel ; Chromate ; Lead ; Benzene ; Dimethylnitrosamine ; 7,12-Dimethylbenzo(a)anthracene ; Anthracene ; Benzo(a)anthracene ; Phenylazoaniline ; N-methyl, N-nitroso, N′-nitroguanidine ; Dioxane ; Pyrene ; Zinc ; Cholesterol ; Benzo(e)pyrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exposure of hamster embryo cells and BF lymphoblastoid cells to 18 known toxic substances and four nominally nontoxic substances results in the release of pyrimidines (and their nucleosides) into the culture medium. The extent of release is dependent on the specific chemical and the specific cells present in the assay. BF cells are not affected by exposure to benzo(a)pyrene, while the hamster embryo cells exhibit enhanced excretion on exposure to benzo(a)pyrene. This difference in response may be due to the difference in endogenous aryl hydrocarbon hydroxylase (BaP) activity. In contrast, diethylstilbestrol, which is metabolized by a peroxidase-mediated enzyme system, causes enhanced excretion in both cell types. Direct alkylating agents and Ni(+2) salts also cause enhanced excretion in both cell types. We have used concentrations of chemicals that give a 5% enhanced excretion as the criterion of low-dose response. Within the range of concentrations tested, chromate induces enhanced excretion in BF cells but not the HEC cells, and Pb(+2) induces enhanced excretion in HEC cells but not the BF cells. Benzene, dimethylnitrosamine, and Mg(+2) did not affect either cell type. 7,12-Dimethylbenzo(a)anthracene, anthracene, benzo(a)anthracene, phenylazoaniline, N-methyl, N-nitroso, N′-nitroguanidine, dioxane, and pyrene cause enhanced excretion in the hamster embryo cells while benzo(e)pyrene, ZnSO4 and cholesterol do not cause enhanced excretion in the hamster embryo cells. Of those chemicals causing enhanced excretion, the concentration range bracketing 5% enhanced excretion approximated low-dose exposures reported to result in toxic responses like cancer, teratogenesis or pulmonary disease.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...