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  • 73C02  (1)
  • Corticosterone  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice (1994)
    Springer
    Psychopharmacology 115 (1994), S. 278-284 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Substance withdrawal syndrome ; Corticosterone ; Ethanol ; Pentobarbital ; Diazepam ; Mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract It has been suggested that withdrawal from several subclasses of central nervous system (CNS) depressants involves common underlying mechanisms. For example, mice genetically selected for severe ethanol withdrawal convulsions (Withdrawal Seizure Prone or WSP) have also been found to express severe withdrawal following treatment with barbiturates and benzodiazepines. Corticosteroids appear to modulate severity of withdrawal from CNS depressants. Therefore, it was hypothesized that corticosterone would enhance withdrawal convulsions following acute ethanol, pentobarbital, and diazepam in WSP mice. Corticosterone (20 mg/kg) administered following each of these drugs significantly increased severity of handling-induced convulsions during withdrawal. Corticosterone did not affect pre-withdrawal convulsion scores or handling-induced convulsions of drug-naive mice. These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02244784
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The invariant manifold of beam deformations (1993)
    Springer
    Journal of elasticity 30 (1993), S. 1-54 
    Details
    ISSN: 1573-2681
    Schlagwort(e): elastic beam theory ; subcentre invariant manifolds ; dynamical systems ; 73C02 ; 73C10 ; 35A35 ; 58G40
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract The subcentre invariant manifold of elasticity in a thin rod may be used to give a rigorous and appealing approach to deriving one-dimensional beam theories. Here I investigate the analytically simple case of the deformations of a perfectly uniform circular rod. Many, traditionally separate, conventional approximations are derived from within this one approach. Furthermore, I show that beam theories are convergent, at least for the circular rod, and obtain an accurate estimate of the limit of their validity. The approximate evolution equations derived by this invariant manifold approach are complete with appropriate initial conditions, forcing and, in at least one case, boundary conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00041769
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