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  • 1
    Electronic Resource
    Electronic Resource
    Die aktivität von Einzelfasern des nervus opticus bei verschiedenen temperaturen (1968)
    Springer
    Experimental brain research 4 (1968), S. 321-329 
    Details
    ISSN: 1432-1106
    Keywords: Temperature ; Interval histograms ; Optic nerve ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 13 Katzen wurde die Aktivität von 128 Einzelfasern des N. opticus bei Temperaturen zwischen 27 und 39° C abgeleitet und direkt einer Intervallanalyse zugeführt. Die Durchschnittsfrequenz sank mit abnehmender Temperatur von 56/sec bei 39–37° C auf 21/sec unter 29° C. Bei Temperaturen über 35° C wurden nur unimodale oder zweigipfelige Verteilungen mit gehäuften Mehrfachentladungen gefunden. Unter 35° C traten multimodale Intervallhistogramme und Übergangstypen auf, bei denen einer Verteilung mehrere Gipfel aufgesetzt erschienen. Unter 29° C wurden nur mehrgipfelige Verteilungen beobachtet. In der phasischen Reaktion der Neurone wurden mit der Temperaturabnahme Latenzen länger und Hemmungen stärker. Unter 30° C konnte der Reaktionstyp des Neurons oft nicht mehr erkannt werden. Das vermehrte Auftreten multimodaler Verteilungen bei niedrigen Temperaturen ließe sich durch Verminderung von Interaktionen in der Retina erklären. Die Anregung zu dieser Untersuchung wurde von Herrn Professor Dr. Hans Bornschein gegeben.
    Notes: Summary The activity of 128 single fibers of the optic nerve was recorded in 13 cats at temperatures between 27 and 39° C. Nonsequential interval histograms were computed on line. Decreasing temperature diminished the mean frequency of the fiber activity from 56/sec at 37–39° C to 21/sec below 29° C. Above 35° C the histograms were unimodal or bimodal, the first peak caused by repetitive discharges. Below 35° C multimodal histograms appeared; in some distributions several peaks were superimposed. At temperatures below 29° C only multimodal distributions were obtained. The phasic response of the neurons to light showed an increase of latency and of inhibition according to the decrease of temperature. Often the type of the response of the neuron could not be recognized below 30° C. During hypothermia interactions in the retina may be reduced and this may explain why multimodal distributions occur more frequently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235699
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of 75Br-labelled butyrophenone neuroleptics for imaging cerebral dopaminergic receptor areas using positron emission tomography (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. 211-216 
    Details
    ISSN: 1619-7089
    Keywords: 75Br ; Bromospiperone ; Brombeperidol ; Bromperidol ; Butyrophenone neuroleptic ; Cerebral dopaminergic receptors ; Postron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative evaluation of three radiobrominated butyrophenone neuroleptics — bromospiperone (BSP), brombenperidol (BBP), and bromperidol (BP) — was made to assess the applicability of these compounds as radiopharmaceuticals labelled with the positron emitter 75Br (T 1/2=1.6 h) for mapping cerebral dopaminergic receptor areas non-invasively with positron emission tomography (PET). BSP, BBP, and BP were prepared in high specific activities with high radiochemical yields, using electrophilic reactions with no-carrier-added 77Br- or 75Br-. Screening tests in rats using 77Br-labelled compounds indicated D2-specific localization for 77Br-BSP and 77Br-BBP, whereas PET experiments in baboons showed that only 75Br-BSP preferentially localized in cerebral tissues rich in dopaminergic receptors. The data suggest an inverse relationship between cerebral uptake and receptor-specific localization, which was attributed to a complicated interplay between the D2 receptor binding affinity, lipophilicity, % ionization and molecular weight of the radioligand, and the binding capacity of the cerebral tissues. 75Br-BSP gave a striatumto-cerebellum ratio of 3 in baboon brain 5 h post-injection, which allowed visualization of dopaminergic-receptor-containing areas of the living brain using PET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256924
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    Paper (German National Licenses)
    Fulltext
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