Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 158-163 
    Details
    ISSN: 1619-7089
    Keywords: S2 serotonin receptors ; Fluoroethylspiperone ; Positron emission tomography ; Neuroreceptor modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used the ligand 3-N-(2′-F 18)fluoroethylspiperone (FESP) and positron emission tomography (PET) to quantify in vivo serotonin S2 neuroreceptor density and affinity in the baboon frontal cortex. In the cortex, FESP binds specifically and exclusively to S2 receptors, and an equilibrium is reached when the rate of ligand-receptor association and dissociation become equal. Using multiple studies in the same baboon, an equilibrium (saturation) analysis approach provided a linear Hill plot with a slope of 1.02 (r 2 =0.988,P 〈0.0001), indicative of ligand binding to a single receptor class. Using serial PET scans, a dynamic approach was also used to quantify S2 receptors in the frontal cortex of the baboon, which provided an estimate of receptor densityB max =35.6 ± 10.9 pmol/g. The rate constants corresponding to transport into and out of tissue wereK * 1 = 0.2720 ± 0.0299 mol/min ⁗ g andk * 2 = 0.0786 ± 0.0315 min−1, respectively. The ligand-receptor dissociation constant wask * 4 = 0.0154 ± 0.0109 min−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262725
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of 75Br-labelled butyrophenone neuroleptics for imaging cerebral dopaminergic receptor areas using positron emission tomography (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. 211-216 
    Details
    ISSN: 1619-7089
    Keywords: 75Br ; Bromospiperone ; Brombeperidol ; Bromperidol ; Butyrophenone neuroleptic ; Cerebral dopaminergic receptors ; Postron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative evaluation of three radiobrominated butyrophenone neuroleptics — bromospiperone (BSP), brombenperidol (BBP), and bromperidol (BP) — was made to assess the applicability of these compounds as radiopharmaceuticals labelled with the positron emitter 75Br (T 1/2=1.6 h) for mapping cerebral dopaminergic receptor areas non-invasively with positron emission tomography (PET). BSP, BBP, and BP were prepared in high specific activities with high radiochemical yields, using electrophilic reactions with no-carrier-added 77Br- or 75Br-. Screening tests in rats using 77Br-labelled compounds indicated D2-specific localization for 77Br-BSP and 77Br-BBP, whereas PET experiments in baboons showed that only 75Br-BSP preferentially localized in cerebral tissues rich in dopaminergic receptors. The data suggest an inverse relationship between cerebral uptake and receptor-specific localization, which was attributed to a complicated interplay between the D2 receptor binding affinity, lipophilicity, % ionization and molecular weight of the radioligand, and the binding capacity of the cerebral tissues. 75Br-BSP gave a striatumto-cerebellum ratio of 3 in baboon brain 5 h post-injection, which allowed visualization of dopaminergic-receptor-containing areas of the living brain using PET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256924
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...