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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of p53 protein and 72 kDa heat shock protein (HSP72) expression in ovarian carcinomas (1995)
    Springer
    Virchows Archiv 425 (1995), S. 603-609 
    Details
    ISSN: 1432-2307
    Keywords: Ovarian carcinoma ; p53 ; Sex steroid receptor ; Immunohistochemistry ; Heat shock protein 72
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutations of the tumour suppressor p53 gene have been reported in a variety of human malignant tumours, and are frequently associated with overexpression of p53 protein. To examine the significance of p53 gene alteration in malignant epithelial tumours of the ovary, we studied the immunohistochemical reactivity with a monoclonal antibody against p53 (PAb 1801) in 6 ovarian tumours of low malignant potential (LMP) and 32 ovarian carcinomas. The existence of any correlation of p53 overexpression with the clinicopathological features and with the immunohistochemical expression of 72 kDa heat shock protein (HSP72) and sex steroid receptors (oestrogen receptors; ER, progesterone receptors; PR) was also analysed. Expression of p53 was found in 2 of the 6 (33.3%) LMP tumours and in 15 of the 32 (46.9%) carcinomas. Strong expression of HSP72 was observed in 11 of the 17 (64.7%) p53-positive tumours, but only in 2 of the 21 (9.5%) p53-negative ones. Histologically, p53-positivity was observed in 7 of the 10 (70%) serous carcinomas, 4 of the 6 (66.7%) mucinous, 4 of the 10 (40%) endometrioid, and none of the 4 clear cell and 2 transitional cell carcinomas. Distribution of p53-positive cells in the tumour sections was homogenous in serous tumours, but heterogenous in mucinous lesions. All of the 4 carcinomas arising in endometriotic cysts were p53-negative. These differences support the thesis of heterogeneity in ovarian carcinogenesis. There was an inverse relationship between p53-positivity and sex steroid receptor status for ovarian carcinomas; 14 of the 15 p53-positive carcinomas were negative for both ER and PR, whereas 11 of the 17 p53-negative carcinomas were positive for ER and/or PR (P〈0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199350
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  • 2
    Electronic Resource
    Electronic Resource
    Hybrid finite analytic solutions of shallow water circulation (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1081-1088 
    Details
    ISSN: 1573-2754
    Keywords: tidal flow ; wind stress ; circulation ; shallow water ; seiche ; hybrid finite analytic method ; density gradient ; P731.2 ; 76M10 ; 76M99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The hybrid finite analytic (HFA) method is a kind of numerical scheme in rectangular element. In order to simulate the shallow circulation in irregular bathymetry by HFA scheme, the model in sigma coordinate system was obtained. The model has been tested against three cases: 1) Wind induced circulation; 2) Density driven circulation and 3) Seiche oscillation. The results obtained in the present study compare well with those obtained from the corresponding analytical solutions under idealized for the above three cases. The hybrid finite analytic method and the circulation model in sigma coordinate system can be used calculate the flow and water quality in estuaries and coastal waters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437640
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    Paper (German National Licenses)
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