ISSN:
1432-0428
Keywords:
Diabetes
;
streptozotocin
;
hypertension
;
type IV collagen
;
7S collagen
;
basement membrane metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The serum concentration of 7S collagen was measured radioimmunologically as a marker of basement membrane type IV collagen synthesis in diabetic and nondiabetic rats with Goldblatt hypertension. In non-diabetic rats the 7S collagen level was significantly raised after induction of hypertension (51%; p〈0.001), and showed a positive correlation with relative heart weight as an integral parameter of hypertension (r= 0.63; p〈0.01). In diabetic rats, which displayed a 7S collagen concentration roughly 2.5 times as high as the metabolically normal animals, the 7S collagen level was 27% higher in the hypertensive animals (p〈0.01). There was no correlation with blood pressure or heart weight, but only a positive correlation with blood glucose (r=0.51; p〈0.05). The results indicate that haemodynamic alterations may alter basement membrane collagen metabolism. However, type IV collagen metabolism in diabetes is influenced to a greater extent by metabolic than by haemodynamic factors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00299028
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