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Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]-and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects (1982)

Hata, T. ; Ogihara, T. ; Nakamaru, M. ; [et al.]

Springer

European journal of clinical pharmacology 23 (1982), S. 7-10

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ISSN: 1432-1041

Keywords: angiotensin II analogues ; angiotensin II receptors ; 1-sarcosine ; 8-threonine angiotensin II ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; plasma aldosterone concentration ; plasma renin activity

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The biological effects of 1-Sarcosine, 8-Threonine angiotensin II ([Sar1, Thr8]ANG II) on blood pressure, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were investigated in six normal subjects on an unrestricted diet, and compared with those of 1-Sarcosine, 8-Isoleucine ANG II ([Sar1, Ile8]ANG II) and 1-Sarcosine, 8-Alanine ANG II ([Sar1, Ala8]ANG II). All three ANG II analogues (A II A) showed agonistic pressor activity, that of [Sar1, Ile8]ANG II being greater than that of [Sar1, Thr8]ANG II or [Sar1, Ala8]ANG II. The antagonistic effect of [Sar1, Thr8]ANG II on blood pressure was less than [Sar1, Ile8]ANG II or [Sar1, Ala8]ANG II. Both [Sar1, Ile8]ANG II and [Sar1, Ala8]ANG II increased PAC and blocked the steroidogenic action of ANG II, while [Sar1, Thr8]ANG II showed little effect on PAC. All three A II A caused similar suppression of PRA and showed no inhibitory effect on the decrease in PRA produced by ANG II. These results indicate that [Sar1, Thr8] ANG II is an A II A with weak agonistic pressor action and that it has vascular selective properties. It is also suggested that ANG II receptors in a variety of target organs are heterogeneous.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01061369

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Phase separation temperatures in the ternary system polystyrene/poly(α-methyl styrene)/cyclopentane (1986)

Saeki, S. ; Tsubotani, S. ; Kominami, H. ; [et al.]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 24 (1986), S. 325-335

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ISSN: 0887-6266

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: Phase separation temperatures of the ternary system polystyrene (PS) (Mw = 1.67 × 104)/poly(α-methyl styrene) (PαMS) (Mw = 9.0 × 104)/cyclopentane with a blend ratio PS/PαMS = 55/45 have been determined over the polymer concentration range 0.02 ≤ ψPS + PαMS ≤ 0.52, where ψ PS + PαMS is the segment fraction of polymer in ternary system. Phase separation temperatures for the upper critical separation in the ternary system decrease with increasing ψ PS + PαMS over the range 0.1 ≤ ψ PS + PαMS ≤ 0.52. The vapor - liquid equilibrium in this system with a blend ratio PS/PαMS=50/50 has been determined over the concentration range 0.925 ≤ ψPS + PαMS 〈 0.995 and the temperature range 60-100°C by the piezoelectric vapor sorption method. The polymer - polymer interaction parameters χ′12 determined are positive except at 100°C and increase with increasing ψ PS + PαMS. Values of χ′12 extrapolated to zero solvent concentration are positive (0.0-1.3) over the temperature range measured. Phase separation behavior is discussed in terms of phase separation temperature in a ternary system and the polymer-polymer interaction parameter.

Additional Material: 6 Ill.