ISSN:
1437-160X
Keywords:
Rheumatoid arthritis
;
IL-1β
;
TNFα
;
IFN-γ
;
Activity index
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Serum cytokines such as interleukin 1β (IL-1β), interferon γ (IFN-γ), and tumor necrosis factor α (TNFα) were measured in 40 patients with rheumatoid arthritis (RA). In the 40 patients studied, serum IL-1β was detected in 5 patients, IFN-γ in 10 patients, and TNFα in 20 patients. The IL-1β-positive group showed increased values of activity indices compared to the IL-1β-negative group. Values of serum IFN-γ correlated well with the number of peripheral blood lymphocytes and CD3+ cells and with the percentage of CD3+ CD26+ cells. Values of serum TNFα correlated positively with the number of peripheral blood monocytes and the percentage of CD3+ HLA-DR+ and CD3+ CD25+ cells. These results indicated that serum IL-1β in RA patients reflects the activity of RA, while the serum IFN-γ and TNFα in RA patients may be related to circulating activated lymphocytes and monocytes, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00286766
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