ISSN:
1432-2072
Keywords:
ACTH
;
Corticosterone
;
Dopamine receptors
;
Apomorphine
;
Haloperidol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of a dopaminergic agonist, apomorphine, and a dopaminergic antagonist, haloperidol, on plasma ACTH, and corticosterone levels were evaluated in adult male rats. Subcutaneous administration of apomorphine in the dose range of 50–500 μg · kg−1 significantly increased plasma corticosterone levels. Acute treatment with apomorphine (250 μg · kg−1) resulted in an elevation of plasma ACTH concentration, peak values being reached 15 min after the injection. The apomorphine-induced rise in plasma ACTH levels was completely inhibited by pretreatment with haloperidol (1 mg · kg−1). A stimulatory role for dopamine receptors in the control of pituitary ACTH release in the rat is suggested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428414
Permalink