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  • 1
    Electronic Resource
    Electronic Resource
    ACTH 4-10 in the amelioration of neuropsychological symptomatology associated with senile organic brain syndrome (1979)
    Springer
    Psychopharmacology 61 (1979), S. 161-165 
    Details
    ISSN: 1432-2072
    Keywords: Senile organic brain syndrome ; ACTH 4-10 ; Polypeptide ; Organon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen male and female volunteers over the age of sixty who exhibited mild senile organic brain syndrome were administered ACTH 4-10 (Org OI 63) (30 mg, s.c.) or saline in a 2×2 Latin square design. Subjects experienced a reduction in depression and confusion and an increase in vigor. This evidence of an increase in vigor was supported behaviorally by a delay in the onset of increased latency in reaction time. Data also indicated that retrieval from memory may be enhanced by this compound. The electroencephalogram evinced a shift to lower frequencies under ACTH 4-10, but this effect was primarily noted in the females who received drug followed by placebo. These effects of ACTH 4-10 are intriguing and suggest that further work in this area should be encouraged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426731
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Methadone effects on brain functioning and type A and B CNV shapes (1979)
    Springer
    Psychopharmacology 65 (1979), S. 21-25 
    Details
    ISSN: 1432-2072
    Keywords: CNV ; Reaction time ; Heart rate ; Attention ; Distraction-arousal hypothesis ; Eye blink-hedonia hypothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve male outpatients participating in a methadone maintenance treatment program were evaluated for the effects of acute administration of methadone on brain functioning (contingent negative variation or CNV), attention performance (reaction time and continuous performance test), and psychophysiological activity (heart rate and eye blink rate). Individual differences in response to methadone were assessed by classifying patients into two groups on the basis of basal CNV shapes: Type A (quick rise time) and type B (slow rise time). Methadone produced a pattern of increased electrical brain activity (CNV) and enhanced attention performance in type B patients and elevated heart rate and lowered eye blink rate in type A subjects. Results are interpreted in terms of the distraction-arousal and the eye blink-hedonia hypotheses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491973
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chlorpromazine effects on brain activity (contingent negative variation) and reaction time in normal women (1975)
    Springer
    Psychopharmacology 43 (1975), S. 293-295 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; CNV ; Reaction Time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electrical brain activity (contingent negative variation or CNV) and psychomotor behavior (reaction time or RT) were measured after 50 mg of chlorpromazine (CPZ) or placebo were given orally to 28 normal women. CPZ reduced CNV 2 and 3 hrs post-drug and slowed RT 3 hrs post-drug. CNV amplitude appears to be an accurate indicator of drug-produced changes in alertness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429268
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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