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  • 1
    Electronic Resource
    Electronic Resource
    Erythropoietic protoporphyria with fatal liver failure (1999)
    Springer
    Journal of gastroenterology 34 (1999), S. 405-409 
    Details
    ISSN: 1435-5922
    Keywords: Key words: erythropoietic protoporphyria ; liver failure ; treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A 33-year-old woman with a history of photosensitivity, persistent abdominal pain, and liver dysfunction was admitted to our department because of abdominal pain and progression of liver dysfunction. On admission, levels of protoporphyrin and coproporphyrin within erythrocytes were markedly increased. Autofluorescent erythrocytes were also detected, leading to a diagnosis of erythropoietic protoporphyria. A liver biopsy specimen revealed cirrhosis with dark brown granules filling hepatocytes, bile canaliculi, and bile ductules. Transfusion of washed erythrocytes, hemodialysis, and administration of cholestyramine and beta-carotene transiently improved levels of porphyrins and liver function. The patient died of rupture of esophageal varices followed by multiple organ failure. However, the treatments were believed to have extended survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050284
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum Vascular Endothelial Growth Factor Levels in Various Liver Diseases (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 41-45 
    Details
    ISSN: 1573-2568
    Keywords: VASCULAR ENDOTHELIAL GROWTH FACTOR ; ACUTE HEPATITIS ; FULMINANT HEPATITIS ; VARIOUS LIVER DISEASES ; HEPATOCYTE GROWTH FACTOR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical significance of circulatingvascular endothelial growth factor (VEGF) in patientswith various liver diseases was investigated. Twenty-onepatients with acute hepatitis (AH), 40 with chronic hepatitis (CH), 34 with cirrhosis (LC), 16 withfulminant hepatitis (FH), 10 with primary biliarycirrhosis (PBC), 12 with autoimmune hepatitis (AIH), and120 healthy individuals were included. Serum VEGF levels were measured by a chemiluminescenceenzyme-linked immunosorbent assay. The mean values ofserum VEGF levels in the patients with AH, CH, LC, FH,AIH, PBC, and control were 172.7, 58.0, 44.1, 37.3, 49.7, 74.9, and 65.0 pg/ml, respectively. Thepatients with AH had a level of serum VEGF significantlyhigher than that of the control group (P 〈 0.001).The serum VEGF levels in survivors of FH weresignificantly increased, but not in the nonsurvivors in therecovery phase compared with the levels on admission (P〈 0.05). In the LC patients, serum VEGF levels weresignificantly lower than those of the control group (P 〈 0.05). These findings suggest thatserum VEGF level may be associated with hepatocyteregeneration grade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018863718430
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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