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  • ADE3  (1)
  • Ty elements  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2 (1989)
    Springer
    Current genetics 16 (1989), S. 315-321 
    Details
    ISSN: 1432-0983
    Keywords: Saccharomyces cerevisiae ; Antisuppressor ; ADE3 ; Translation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNAfmet. The role of this enzyme in translational fidelity had not previously been suspected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340709
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The same configuration of Ty elements promotes different types and frequencies of rearrangements in different yeast strains (1988)
    Springer
    Molecular genetics and genomics 211 (1988), S. 272-281 
    Details
    ISSN: 1617-4623
    Keywords: Yeast ; Ty elements ; Recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We examined Ty-mediated genomic rearrangements in three related mitotically dividing haploid yeast strains having the same configuration of Ty elements in the CYC1-sup4 interval of chromosome X. Surprisingly, quite different types and frequencies of rearrangements were found in the three strains. In one strain we found only Ty-mediated deletions, which occurred with a frequency of about 1×10-6. Another strain yielded similar deletions, but approximately one-third of these were accompanied by adjacent Ty-mediated inversions. A third strain was found to have an extremely high rate of inversion/reinversion between two of the three Ty elements. This rate was conservatively estimated to be 1.4±0.2×10-2 per cell per generation, which is at least 2 orders of magnitude higher than previously reported values for Ty-mediated rearrangements. These data provide evidence that local regions of the genome can, in some cases, be much more fluid than had been previously believed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330604
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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