ISSN:
1619-7089
Keywords:
AIDS
;
Pneumocystis carinii pneumonia
;
Indium-111
;
Human immunoglobulin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Functional imaging is ideally suited to monitoring the effect of specific therapy on disease processes. In this pilot study five patients with AIDS and Pneumocystis carinii pneumonia (PCP) were imaged with Indium-111 labelled pooled human immunoglobulin (111In-HIG) during infection and after therapy for PCP. The lung activity of t t tln-HIG, measured as a lung/heart ratio, was calculated in a study performed during infection with PCP and after therapy. In all five patients the lung/heart ratio of t t 1ln-HIG was reduced after treatment. The mean reduction in heart/lung ratio was 27% (range 12%-53%). If these results are confirmed by a larger study, 11In-HIG will be useful in monitoring the response of PCP to therapy in patients with AIDS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00181072
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