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  • 1
    Electronic Resource
    Electronic Resource
    ASHAP – an effective salvage therapy for recurrent and refractory malignant lymphomas (2000)
    Springer
    Annals of hematology 79 (2000), S. 304-311 
    Details
    ISSN: 1432-0584
    Keywords: Key words Hodgkin's disease ; Non-Hodgkin's lymphoma ; Salvage therapy ; ASHAP protocol ; High-dose therapy ; Autologous stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: This study was performed to examine the efficacy and toxicity of the combination of adriamycin (ADR), methylprednisolone (solumedrol), cytarabine (Ara-C), and cisplatin (CDDP) in patients with recurrent and refractory malignant lymphomas. Patients and methods: Sixty-five patients with Hodgkin's disease (HD) (n=14) or non-Hodgkin's lymphomas (NHL) (n=51) were enrolled in the study. The ASHAP therapy consisted of ADR (40 mg/m2 by continuous infusion (CI) over 96 h), methylprednisolone (500 mg i.v., days 1–5), Ara-C (2 g/m2 as a 2-h infusion on day 5), and CDDP (100 mg/m2 by CI over 96 h). Results: Twenty-five patients (38%) achieved complete remission (CR) and 20 (31%) were taken into partial remission (PR) for an overall response rate of 69%. Thirty-two patients with CR or PR following ASHAP underwent high-dose therapy (HDT) with subsequent hematopoietic stem cell transplantation. After a median follow-up of 52 months, 13 patients are in continuous CR (CCR), the 3-year event-free survival (EFS) was 30% for responders and 21% for all patients. The median overall survival (OS) was 12 months (range 0–70 months), and the OS rate after 3 years was 32%. Unfavorable prognostic factors for EFS and OS by univariate analysis were an elevated value of the serum lactate dehydrogenase and refractory lymphoma. The most frequently observed side effects following ASHAP were leukocytopenia and thrombocytopenia of World Health Organization (WHO) grades III/IV in approximately 80% of all courses. Non-hematological toxicities such as gastrointestinal side effects, infections, mucositis, renal and neurotoxicity occurred more rarely and reached WHO grades III/IV only occasionally. No treatment-related mortality with ASHAP was observed. Conclusions: ASHAP is an effective and moderately toxic salvage therapy for patients with recurrent or refractory HD and NHL. The results in patients responding to ASHAP and afterwards undergoing HDT with stem cell support are comparable with other established protocols and indicate an improvement in survival if HDT is carried out as intensification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002779900150
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  • 2
    Electronic Resource
    Electronic Resource
    Low-dose cytosine-arabinoside in the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) (1984)
    Springer
    Annals of hematology 48 (1984), S. 239-242 
    Details
    ISSN: 1432-0584
    Keywords: AML ; MDS ; Low dose ARA-C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten AML- and two MDS-patients in whom conventional chemotherapy was contraindicated or ineffective were treated with low dose ARA-C, 10 mg/m2 per 12hs.c. for 2–4 weeks. Seven patients obtained a complete and two a partial remission. Our findings suggest that low dose ARA-C may act both by induction of differentiation and/or inhibition of proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319816
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  • 3
    Electronic Resource
    Electronic Resource
    Prognostic significance of chromosome analysis in de novo acute myeloid leukemia (AML) (1988)
    Springer
    Annals of hematology 56 (1988), S. 19-26 
    Details
    ISSN: 1432-0584
    Keywords: Cytogenetic studies ; AML ; Prognostic value
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1981 and 1986 cytogenetic studies of bone marrow and/or blood cells in 139 patients with de novo acute myeloid leukemia (AML) were performed. The overall incidence of chromosomal aberrations was 53%, and this was not significantly influenced by sex, age nor the FAB classification. The aberrations most often found were: complex anomalies (n=13), t(8; 21) (n=10), trisomy 8 (n=9), monosomy 7 (n=6), monosomy 5, 5q-, trisomy 11, 12p- (n=4) and trisomy 6, 11q-, inv [16] (n=3). The prognostic significance of chromosomal findings was evaluated in 112 patients treated by combination chemotherapy. The chromosomal status NN, AN, AA did neither significantly influence complete remission rate (NN: 68%, AN: 71%, AA: 60%) nor mean survival (NN: 24, AN: 26.6, AA: 35.6 months). On the other hand, certain types of chromosomal anomalies were of prognostic value. CR was obtained in all 10 patients with t(8; 21) but only in 2 out of 9 patients with complex aberrations. Median duration of CR in patients with t(8; 21) was significantly longer than in patients with a normal karyotype (30 vs 7 months).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321055
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  • 4
    Electronic Resource
    Electronic Resource
    Translocation t (4; 11) in acute lymphocytic leukemia (ALL) (1982)
    Springer
    Annals of hematology 44 (1982), S. 271-274 
    Details
    ISSN: 1432-0584
    Keywords: ALL ; Chromosome analysis ; Translocation t (4; 11)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two patients with acute lymphocytic leukemia are described in whom G- and R-banding analysis revealed in bone marrow cells a translocation t (4; 11) (q21; q23). The clinical data are compared to the other four cases with t (4; 11) reported so far in the literature. The anomaly seems to be characteristic for ALL. In addition it appears to be associated with a very high number of circumlating blasts and other poor prognostic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320701
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    Paper (German National Licenses)
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