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  • APACHE  (1)
  • Adult respiratory distress syndrome  (1)
  • CD3SCD3  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    ARDS after accidental inhalation of zinc chloride smoke (1988)
    Springer
    Intensive care medicine 14 (1988), S. 17-24 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Adult respiratory distress syndrome ; Zinc chloride toxicity ; Acute lung injury
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Five soldiers were injured by inhalation of hexite smoke (ZnCl2) during military training. Two soldiers, not wearing gas masks breathed hexite for 1 or 2 min, they slowly developed severe adult respiratory distress syndrome (ARDS) over the ensuing 2 weeks. This slow, progressive clinical course has not been previously described. In both patients, an increased plasma zinc concentration was measured 3 weeks after the incident. Intravenous and nebulized acetylcysteine increased the urinary excretion of zinc, and briefly decreased the plasma levels. In an attempt to arrest collagen deposition in the lungs, L-3,4 dehydroproline was administered. Both patients died of severe respiratory failure (25 and 32 days after inhalation). At autopsy diffuse microvascular obliteration, widespread occulusion of the pulmonary arteries and extensive interstitial and intra-alveolar fibrosis was observed. Three soldiers wearing ill fitting gas masks, immediately developed severe coughing and dyspnea. They improved, and 12 months after exposure their lung function tests were nearly normal, but they still had slight dyspnea on exercise.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00254116
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Severity of illness and outcome of treatment in alcoholic patients in the intensive care unit (1988)
    Springer
    Intensive care medicine 15 (1988), S. 19-22 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Alcoholics ; APACHE ; TISS ; Mortality ; ICU
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To study whether critically ill alcoholics were more sick and had a worse outcome than other patients treated in the intensive care unit, data were collected during the initial 24 h on 216 consecutive patients admitted to an intensive care unit. Twentysix patients (12%) met the criteria for alcohol abuse. The patients' chronic health 6 months prior to admission and the extent of physiological derangement (Acute Physiology Score and Chronic Health Evaluation (APACHE)) were recorded just as the type and amount of treatment (Therapeutic Intervention Scoring System (TISS)). Alcoholics were found to be significantly more sick and had a higher mortality (50% compared to 26%) than other critically ill patients. However, when analyzing the TISS points, no difference was found between the two groups. All survivors were, every third month up to 1 year after admission, asked to fill in a questionnaire indicating their level of activity. No differences were found between the two groups 1 year after admission, but the alcoholics had lost more time due to death. It is concluded that studies with larger number of patients will reveal whether alcogolics constitute a special category of patients with a different prognosis than other ICU patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00255630
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  • 3
    Digitale Medien
    Digitale Medien
    Products and mechanisms of the gas phase reactions of NO3 with CH3SCH3, CD3SCD3, CH3SH and CH3SSCH3 (1992)
    Springer
    Journal of atmospheric chemistry 14 (1992), S. 95-108 
    Details
    ISSN: 1573-0662
    Schlagwort(e): Products ; mechanism ; NO3 ; gas phase ; CH3SCH3 ; CD3SCD3 ; CH3SH ; CH3SSCH3 ; isotope effect ; air ; troposphere
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Geologie und Paläontologie
    Notizen: Abstract Products and mechanisms of the reaction between the nitrate radical (NO3) and three of the most abundant reduced organic sulphur compounds in the atmosphere (CH3SCH3, CH3SH and CH3SSCH3), have been studied in a 480 L reaction chamber using in situ FT-IR and ion chromatography as analytical techniques. In the three reactions, methanesulphonic acid was found to be the most abundant sulphur containing product. In addition the stable products SO2, H2SO4, CH2O, and CH3ONO2 were identified and quantified and thionitric acid-S-methyl ester (CH3SNO2) was observed in the i.r. spectrum from all of the three reactions. Deuterated dimethylsulphide (CD3SCD3) showed an isotope effect on the reaction Deuterated dimethylsulphide (CD3SCD3) showed an isotope effect on the reaction rate constant (kH/kD) of 3.8±0.6, indicating that hydrogen abstraction is the first step in the NO3+CH3SCH3 reaction, probably after the formation of an inital adduct. Based on the products and intermediates identified, reaction mechanisms are proposed for the three reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00115226
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