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  • ARIMA  (1)
  • Antagonist  (1)
  • Antidiabetic drugs  (1)
  • Central norepinephrine lesions  (1)
  • 1
    ISSN: 0196-9781
    Keywords: Antagonist ; Pancreatic acini ; Secretin ; Somatostatin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 42 (1992), S. 151-154 
    ISSN: 1432-1041
    Keywords: Antidiabetic drugs ; drug utilization ; health care systems ; Spain ; DDD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The consumption of antidiabetic drugs in a Spanish region (Extremadura) in the period 1986–1987 has been investigated by the “defined daily dose” (DDD) method. The study was done in three health care systems in the region: civil servants (“Mutualidad de Funcionarios Civiles del Estado: MUFACE”) armed forces group (“Instituto Social de las Fuerzas Armadas: ISFAS”) and the national system (“Instituto Nacional de la Salud: INSALUD”). The total consumption of antidiabetic drugs varied three-fold, ranging from 5,73 DDD per 1000 inhabitants per day (3,71 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 2,02 DDD per 1000 inhabitants per day for insulin) in the civil servant group to 15,82 DDD per 1000 inhabitants per day (12 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 3,82 DDD per 1000 inhabitants per day for insulins) in the armed forces. The differences were more pronounced for oral antidiabetics than for insulins. The utilization of insulin among the civil servants was about half of that by the two other groups. Of oral antidiabetics, sulphonylureas were the most frequently used by the three groups, and within them glibenclamide accounted for more than half of the DDDs, while biguanides were scarcely used in any group. The differences are difficult to assess, since they could be due to several factors, such as age-differences in the population studied, different prescribing habits, and differences in sociocultural level. The results justify further comparative studies of drug utilization in different health systems within the same region.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 72 (1999), S. 366-376 
    ISSN: 1432-1246
    Keywords: Key words Pollution ; Morbidity ; Mortality ; ARIMA ; Time series ; Weather
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Evaluation of the association between air pollution and mortality and morbidity is becoming ever more complex owing to changes in inner-city air pollution, marked by decreasing values for all main pollutants save those associated with traffic. This has led to the need for the study of new epidemiological scenarios in which most pollutants are below guideline values. Nonetheless, the health effects are significant. Methods: This report presents the results of a statistically based model for real-time forecasting of mortality and morbidity in Madrid, with meteorological and pollution series serving as inputs. Results and conclusions: Not only did the models perform well with correlation coefficients between predicted and observed values (r = 0.683 for mortality, r = 0.681 for morbidity), but they enabled quantification of the impact of air pollution on mortality and morbidity (with increases ranging from 1.8% to 12% for mortality and from 2.3% to 18% for morbidity for a 25-μg/m3 increase in pollutants). Moreover, attention should be drawn to the observation that the model proved to be easy to implement and operate on a routine basis.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1106
    Keywords: Central norepinephrine lesions ; Enriched environments ; Functional recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult rats were injected intraventricularly with 6-OHDA and allowed to recover for varying time periods in either an enriched colony environment or in isolation cages. When tested behaviorally in a novel environment, isolated animals showed a cyclical recovery pattern, with behavioral changes at 14 days after lesioning which were different from those seen at 2 and 45 days after lesioning. In contrast, animals housed in a colony environment showed progressive improvement and better recovery than isolates. Biochemical studies of uptake of H3NE and histofluorescence indicated that colony housed animals had enrichment effects (higher cortical NE uptake), but they were also more susceptible to 6-OHDA and did not recover well from the lesions. Isolated animals showed somewhat better recovery of NE uptake following 6-OHDA injections, especially in cortex. Because behavioral recovery from 6-OHDA was dissociated from biochemical indicators of recovery in NE circuitry, these results imply that brain systems other than NE were primarily responsible for the enhanced behavioral recovery which occurs in enriched environments.
    Type of Medium: Electronic Resource
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