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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 1111 (1992), S. 204-210 
    ISSN: 0005-2736
    Keywords: Aqueous boundary layer ; Caco-2 ; Drug absorption ; Intestinal epithelium ; Permeability ; Unstirred water layer
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Guinea pig myocytes ; Ca2+-current ; Rundown ; Calpain I/II ; Calpastatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The decrease (‘run-down’) of the L-type Ca2+-current during long-lasting recordings with the whole-cell patch-clamp technique was examined in guinea pig ventricular myocytes. We have tested whether proteolysis is involved in the decay of the Ca2+-current by intracellular application of several concentrations of the Ca2+-dependent proteases calpain I and II, as well as their endogenous inhibitor calpastatin. The major finding was that calpain I and calpain II accelerated the Ca2+-current run-down in a concentration dependent manner, whereas calpastatin retarded it. These observations indicate that a proteolytic degradation of Ca2+-channels might be the reason for the run-down phenomenon.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 52 (1984), S. 243-246 
    ISSN: 1439-6327
    Keywords: Lactate ; Glycogen ; ATP ; Creatine phosphate ; Glucose ; Glucose-6-phosphate ; Arm exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five elite flatwater kayak paddlers were studied during indoor simulated 500 and 10,000-m races, with performance times of 2 and 45 min, respectively. Muscle biopsies were obtained from the midportion of m. deltoideus immediately pre and post exercise. Concentrations of adenosine triphosphate (ATP), creatine phosphate (CP), glucose, glucose-6-phosphate (G-6-P), glycogen, and lactate were subsequently determined. Short term exercise resulted in statistically significant increases in glucose (P〈0.001), G-6-P (P〈0.05) and lactate (P〈0.01) concentration concomitant with decreased CP (P〈0.05) and glycogen (P〈0.01). Following prolonged exercise, a non-significant elevation in glucose and a reduction (P〈0.01) in glycogen were demonstrated. Evidently the metabolic demands for kayak competitions at 500 and 10,000 m are different. Thus, the energy contribution from glycolytic precursors and the anaerobic component is of greater relative importance in short distances than in exercise of long duration. A generalization of the findings to other athletic events of varying distances is proposed. The present data on arm-exercise is consistent with previous findings obtained in connection with leg exercises.
    Type of Medium: Electronic Resource
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