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  • ATP-K+ channels  (1)
  • Periplaneta americana  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels (1990)
    Springer
    Pflügers Archiv 415 (1990), S. 479-483 
    Details
    ISSN: 1432-2013
    Keywords: Glucose ; Hypothalamic neurones ; ATP-K+ channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracellular recordings were made from neurones located in the ventromedial hypothalamic nucleus (VMHN) of slices from rat hypothalamus. These neurones were hyperpolarized on removal of extracellular glucose, resulting in an inhibition of firing, actions which were reversed on the re-introduction of glucose. No reversal of the inhibition of firing was observed when 10 mM mannoheptulose an inhibitor of glucose metabolism, was present in addition to glucose. Increasing the mannoheptulose concentration to 20 mM resulted in further hyperpolarization. Cell-attached recordings from isolated neurones revealed that an increase in extracellular glucose inhibited a K+ channel and increased action current activity. ATP induced closure of this K+ channel when applied to inside-out membrane patches. Closure was also induced by Mg-free ATP or the nonhydrolysable ATP-analogue, adenylylimidodiphosphate indicating no requirement for ATP metabolism. We suggest that the closure of ATP-sensitive potassium channels underlies increased hypothalamic firing following an increase in extracellular glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373626
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Haemocyte involvement in the repair of the insect central nervous system after selective glial disruption (1986)
    Springer
    Cell & tissue research 243 (1986), S. 367-374 
    Details
    ISSN: 1432-0878
    Keywords: Haemocytes ; Glia ; Central nervous system ; Repair ; Insect ; Periplaneta americana
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Injection of physiologically inert particles (fluorescent microspheres) has a profound effect on neural repair of central nervous connectives of the cockroach Periplaneta americana following selective glial disruption. The injected particles, which do not gain direct access to the central nervous tissues, are taken up by a relatively small proportion (〈 10%) of the haemocytes. This interference with haemocyte function virtually abolishes the appearance of the granule-containing cells (which are prominently involved in normal glial repair) and produces abnormal reorganization of the superficial glial elements. These results are interpreted as evidence that the granule-containing cells are derived from haemocytes which are critically involved in glial repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251053
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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