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  • 1
    Electronic Resource
    Electronic Resource
    A biphasic change in contractile proteins during the development of cardiac hypertrophy in pigs (1987)
    Springer
    Basic research in cardiology 82 (1987), S. 1-8 
    Details
    ISSN: 1435-1803
    Keywords: cardiac hypertrophy ; myosin ATPase ; actin-activated myosin ATPase ; myofibrillar ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A non-failing hypertrophy of the left ventricle was produced in the pig heart by supravalvular banding of aorta for 4, 8 and 12 weeks and the myosin and myofibrillar adenosine triphosphatase activities were measured. A significant increase in myosin Ca2+-ATPase activity was seen at 4 weeks of hypertrophy, but at 8 and 12 weeks this activity was significantly decreased compared to sham control. Similar changes were also seen in actin-activated myosin ATPase activities at 4, 8 and 12 weeks of hypertrophy. There were no changes in the K+- and NH4 +-EDTA-stimulated ATPase activities of myosin. Basal ATPase activities of myofibrils were decreased at 4 and 8 weeks of hypertrophy and there was no change in this activity at 12 weeks of hypertrophy. Ca2+ stimulated ATPase activity of myofibrils was significantly increased at 4 weeks, normal at 8 weeks and significantly reduced at 12 weeks of hypertrophy. The changes in ATPase activities were not due to any alterations of proteins by high concentrations of salts during the purification of myosin. The non-hypertrophied right ventricle from the banded animals did not show any change in the basal or Ca2+ stimulated myofibrillar ATPase activities. It is suggested that hypertrophy of the myocardium is accompanied by specific changes in the enzyme activities of the contractile proteins and the biphasic responses may correlate with the functional state of the myocardium subjected to a chronic increase in pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907047
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alterations in the heart sarcolemmal Ca2+ transport activity by some β-adrenergic antagonists (1984)
    Springer
    Basic research in cardiology 79 (1984), S. 620-626 
    Details
    ISSN: 1435-1803
    Keywords: heart sarcolemma ; Ca2+-stimulated ATPase ; ATP-dependent Ca2+ binding ; β-adrenergic antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of some β-adrenergic antagonists such as acebutolol, propranolol, pindolol and oxprenolol (1–1000 μM) were studied on the rat heart sarcolemmal Ca2+ transport activities. Pindolol enhanced sarcolemmal ATP-dependent Ca2+ binding and Ca2+-stimulated ATPase whereas acebutolol had no effect. Both propranolol and oxprenolol had biphasic actions on the sarcolemmal Ca2+ pump activities; the lower concentrations (1 and 10 μM) were stimulatory, but the higher concentrations (100 and 1000 μM) were inhibitory. None of the drugs used in this study had any effect on Mg2+ ATPase and non-specific Ca2+ binding activities of heart sarcolemma except that 1000 μM propranolol decreased Mg2+ ATPase activity significantly. Mitochondrial and microsomal ATP-dependent Ca2+ binding activities were unaffected by these drugs (1–1000 μM), except that 1000 μM propranolol was inhibitory. These results suggest differences among various β-adrenergic blocking drugs with respect to their actions on sarcolemmal Ca2+ pump in the myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908380
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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