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  • 1
    Electronic Resource
    Electronic Resource
    Loss of blood group antigen a in non-small cell lung cancer (1994)
    Springer
    Annals of surgical oncology 1 (1994), S. 423-427 
    Details
    ISSN: 1534-4681
    Keywords: Blood group A ; Lung cancer ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Many human tumor cells display alterations in blood group antigen expression, and the loss of antigen A expression by non-small cell lung cancer (NSCLC) in blood group A patients has recently been associated with decreased survival. Methods: To confirm this finding, we performed a retrospective study of 62 NSCLC patients undergoing potentially curative resection between August 1987 and December 1991 who were blood group A and had paraffin-embedded primary lung cancer tissue suitable for immunohistological analysis of antigen A expression. Twenty-seven patients expressed antigen A in their tumors, whereas 35 had loss of antigen expression. Disease-free survival (DFS) curves were calculated for stage I (n=26) and IIIA (n=25) patients. Results: The two groups of patients with or without antigen A expression did not have significantly different DFS. A proportional hazards regression analysis identified no significant difference in the DFS of stage I patients with or without antigen A, but stage IIIA patients who had preservation of antigen A had significantly shorter DFS than did those who lost antigen A (p=0.0002). Conclusions: The loss of expression of antigen A by primary tumor cells was not a significant adverse prognostic factor in DFS in our series, and we would recommend further studies to define clearly the clinical importance of antigen A expression in pulmonary carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303816
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transition-state structures for describing the enzyme-catalyzed mechanisms of rubisco (1999)
    Springer
    Theoretical chemistry accounts 101 (1999), S. 234-240 
    Details
    ISSN: 1432-2234
    Keywords: Key words: Rubisco mechanism ; Transition-state structures ; Ab initio calculations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract. The carboxylation and oxygenation processes of a model substrate, 3,4-dihydroxy-2-pentanone, have been theoreticaly characterized as a set of steps, mimicking the corresponding reactions of D-ribulose-1,5-bisphosphate catalyzed by rubisco. A theoretical characterization is carried out of transition-state structures and possible molecular intermediates represented as saddle points of index 1 and minimum energy structures, respectively. The quantum chemical characterization, at the HF/3-21G calculation level, of these stationary points is used to rationalize and to discuss both catalyzed sequences. The reported set of these stationary points maps out most experimental aspects of the reaction pathways for the real system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002140050435
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    H-point standard additions method for resolution of overlapped chromatographic peaks with a conventional fluorescence detector. Determination of phenol and cresols in waters (1996)
    Springer
    Chromatographia 42 (1996), S. 283-289 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Peak overlap ; Fluorescence detection ; H-Point standard additions method ; Water analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The H-Point Standard Additions Method (HPSAM) is proposed in order to resolve overlapping peaks in liquid chromatography by using a conventional fluorescence detector. The method uses as analytical signals the heights or the areas obtained at two previously selected emission wavelengths, and good results are obtained for highly overlapping peaks with highly overlapping fluorescence spectra. The principal benefits of the method are the ease of finding the required wavelengths, its insensitivity to changes in the retention time of the peak from one injection to another, and the possibility of using it in highly or only partially overlapping peaks. We have applied the method to the determination of phenol and cresols in water, resolving by the proposed method the overlapping peaks ofm- andp-cresol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290310
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    Paper (German National Licenses)
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