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  • Abbott compound 086719.1  (1)
  • Column liquid chromatography  (1)
  • Lacanobia oleracea  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The role of Pimpla hypochondriaca venom in the suppression of pupal Noctuid host immunity (1999)
    Springer
    Entomologia experimentalis et applicata 93 (1999), S. 289-296 
    Details
    ISSN: 1570-7458
    Keywords: Pimpla hypochondriaca ; venom ; insect immunity ; Lacanobia oleracea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract When pupae of the Tomato moth (Lacanobia oleracea L.) (Lepidoptera: Noctuidae) are injected with venom from the endoparasitoid wasp Pimpla hypochondriaca Retzius (Hymenoptera: Ichneumonidae), they show an increased susceptibility to the fungal entomopathogen Metarhizium anisopliae Sorokin (Fungi Imperfecti: Deuteromycotina). This observation, coupled with the fact that wasp eggs are comparatively unlikely to be encapsulated when implanted into envenomated pupae, suggests that venom of P. hypochondriaca suppresses the cellular immune defense mechanisms of L. oleracea. Injection of host pupae with the venom of P. hypochondriaca has a rapid, adverse effect on the normal respiration pattern of L. oleracea. It is possible that severe disruption to host-metabolism may contribute to a general failure in the hosts' normal immune response repertoire.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003923106201
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of 8[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride and related substances by high performance liquid chromatography (1995)
    Springer
    Chromatographia 41 (1995), S. 141-147 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Fluoroquinolones ; Quinolizines ; Impurity Profile ; Abbott compound 086719.1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The purity of the investigational antibacterial Abbott-086719.1 (I) which is 8[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride is determined using gradient elution HPLC. The chromatographic separation was optimized and the chromatographic parameters critical to separation are discussed in detail. Most acceptable separations were achieved using an Alltima C18 column (5 μm) measuring 4.6 mm I.D.×15 cm with 0.01M–0.03M citrate eluents which were modified with acetonitrile or with mixtures of acetonitrile and methanol. Related substances in I were determinable to 0.05%. Repeatability (RSD values) for determining related substances at levels of 0.50 to 0.06% ranged from ±1.9 to ±10%. Determinations of I in 5% dextrose in water and in hydroxypropyl methylcellulose were made using the same column and a simple isocratic system. The determination of I was stability indicating with precision (RSD values) of ±0.5% to ±2.0% and good agreement with theory for formulations containing I at 1.0 to 95 mg/mL concentrations. Recoveries of I from the vehicles were quantitative and linearity of the detector response of I was demonstrated to at least 0.10 mg/mL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267945
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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