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  • 1
    Electronic Resource
    Electronic Resource
    Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse (1979)
    Springer
    Psychopharmacology 61 (1979), S. 281-285 
    Details
    ISSN: 1432-2072
    Keywords: Writhing ; Δ 9-Tetrahydrocannabinol ; Cannabidiol ; Abdominal constriction ; Drug interactions ; Cannabinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of Δ 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8α,11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective antagonist against all nociceptive agents with an ED50 in all cases between 1.0 and 2.6 mg/kg. CBN, while also effective against all nociceptive agents, was less potent than THC, with an ED50 range between 46.2 and 112.5 mg/kg. CBD in doses as high as 200 mg/kg was without effect. Using PGE1 as the nociceptive agent, 11-OH THC was equipotent to THC while 8α,11-diOH THC was inactive. Naloxone, while able to antagonise the antinociceptive effect of morphine against formic acid-induced writhing, did not reverse the antinociceptive effects of THC. There were no pharmacological interactions between THC, CBD and CBN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432273
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The interaction between prostaglandin E1 andΔ 9-Tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse (1976)
    Springer
    Psychopharmacology 47 (1976), S. 187-193 
    Details
    ISSN: 1432-2072
    Keywords: Δ 9-tetrahydrocannabinol ; Prostaglandin E1 ; Intestinal motility ; Abdominal constriction ; Drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction betweenΔ 9-tetrahydrocannabinol (THC) and PGE1 was studied using two pharmacological parameters-the rate of passage of a charcoal meal through mouse small intestine and the abdominal constriction response in the mouse. PGE1 administered intraperitoneally produced a dose-dependent decrease in intestinal motility, and this effect was antagonized by low (0.25 mg/kg) doses of THC and potentiated by higher doses of THC (1 mg/kg). Kinetic analysis suggested that the interaction was of a mixed but predominantly competitive type. PGF2α produced an increase in intestinal motility but this was not dose-dependent. THC antagonized the effect of PGF2α in a dose-dependent manner suggestive of a physiological antagonism. THC (0.25–2 mg/kg) antagonized the dosedependent PGE1 abdominal constriction response in a fashion which suggested a mixed (though mainly competitive) antagonism. It would seem, therefore, that on the two pharmacological parameters studied THC appears to be interacting with PGE1 at the same receptor site. Although the doses of THC used are within the range of those used in man, it is not implied that these results are necessarily implicated in the psychoactivity of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735820
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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