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  • 1
    Electronic Resource
    Electronic Resource
    The fine structure of adrenal zona glomerulosa in the adult rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 235-243 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal zona glomerulosa ; Rat ; Normal ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This paper reports on an electron microscopic study of the adrenal zona glomerulosa in the normal rat, with special emphasis on the structural diversity of mitochondria in its parenchymatous cells. The mitochondria of cristae may be tubulo-vesicular, plate-like and/or straight tubular, any one mitochondrion containing one or more types of cristae. The mitochondrial features of the zona glomerulosa parenchymatous cells are attributed to the biochemical stages of aldosterone synthesis, taking place in different mitochondria of these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222276
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on the pharmacokinetics of bis-quaternary ammonium compounds (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 251-261 
    Details
    ISSN: 1432-1912
    Keywords: Tritium-Labelled Hexamethonium Derivatives ; Whole Body Autoradiography ; Distribution ; Accumulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On each nitrogen atom of 3H-hexamethonium one methyl group was replaced either by a n-propyl, N-n-propylphthalimide or n-nonyl group. By means of whole-body autoradiography the influence of the different substituents on the distribution pattern was studied in mice after i.v. or s.c. injection. Increasing the chain length of the substituents caused an enhanced accumulation of the respective compounds into secreting tissues, heart muscle, and liver, and an augmentation of biliary excretion. The affinity of the bis-quaternary ammonium compounds for cartilaginous tissues was also altered. The physiological “barriers” between blood and brain or blood and the aqueous humor of the eye, were highly effective against the compounds studied, whereas the placenta could be penetreted by these derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500054
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Studies on the pharmacokinetics of bis-quaternary ammonium compounds (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 270 (1971), S. 419-427 
    Details
    ISSN: 1432-1912
    Keywords: Tritium Labelled Hexamethonium ; Whole Body Autoradiography ; Distribution ; Accumulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Distribution and accumulation of intravenously and subcutaneously injected tritium-labelled hexamethonium has been studied in mice using autoradiography of whole body sections. The bis-quaternary ammonium compound is rapidly distributed over the organism and excreted mainly by the kidneys, less with the bile. Due to its affinity to “negative binding sites” it combines with acid mucopolysaccharides and is accumulated therefore considerably in connective and cartilaginous tissues. 30 min after either injection route the general distribution pattern of hexamethonium in the organism is characterized as follows (decreasing order): Kidneys, urinary tract, cartilage and connective tissue ≫ lungs 〉 blood, liver 〉 heart and skeletal muscle, gastric and intestinal wall 〉 spleen 〉 adipose tissue, brain and spinal cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002352
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Multiple rough endoplasmic cisternae in “C” cells (1976)
    Springer
    Cell & tissue research 170 (1976), S. 89-94 
    Details
    ISSN: 1432-0878
    Keywords: “C” cells ; Endoplasmic reticulum ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Multiple rough endoplasmic cisternae were found in “C” cells of the adult rat, at interphase. They are considered to be normal constituents of “C” cells. Their morphological relation to rough endoplasmic reticulum and their close proximity to mitochondria, Golgi dictyosomes and secretory granules suggest that they may have a role in the secretory activity of this endocrine cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220112
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple rough endoplasmic cisternae in the endocrine pancreas of the adult rat (1975)
    Springer
    Cell & tissue research 160 (1975), S. 539-549 
    Details
    ISSN: 1432-0878
    Keywords: Endocrine pancreas ; Adult rat ; Endoplasmic reticulum ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Multiple rough endoplasmic cisternae were found in the parenchymatous cells of the endocrine pancreas of the adult rat (alpha, beta, D and intermediary cells) and were especially developed in beta cells. They are considered to be normal constituents of the parenchymatous cells of the endocrine pancreas. Their close proximity to Golgi dictyosomes and the accumulation of secretory material sometimes seen at the extremities of such cisternae, suggest that they may have a role in the secretory activity of these endocrine cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225770
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    Paper (German National Licenses)
    Fulltext
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