ISSN:
1433-8580
Keywords:
Ethanol
;
Acetaldehyde
;
Liver injury
;
Cyanamide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Extremely high concentrations of hepatic acetaldehyde were induced in rats by the intragastric administration of ethanol and cyanamide, an aldehyde dehydrogenase inhibitor; and these high levels were maintained for 4 weeks. Liver function tests, including mitochondrial ornithine carbamoyltransferase (OCT) and GOT activities, were within normal limits, and no increase in either hepatic triglyceride or collagen contents was observed. These results suggest that hepatotoxic effects of ethanol are not derived from the high acetaldehyde levels in the liver.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852036
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