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  • 1
    Electronic Resource
    Electronic Resource
    Neurobehavioral tests in single- and repeated-dose toxicity studies in small rodents (1983)
    Springer
    Archives of toxicology 54 (1983), S. 1-23 
    Details
    ISSN: 1432-0738
    Keywords: Neurobehavioral testing ; Motor activity ; Emotionality ; Social interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The discovery of neurobehavioral hazards is an important goal of the majority of the toxicological studies. Quite often it is possible to detect signs of neurobehavioral toxicity through non-instrumental observations and from the response of the animals to simple manipulations. Psychopharmacologists have long used these techniques to identify new drugs with potential usefulness as psychotropic agents. Their approach may also be applicable for the detection of neurotoxic chemicals. Based on a review of the literature and personal experience a neurobehavioral check-list is proposed which can easily be incorporated into the animal care and treatment routine used in single- and repeated-dose toxicity studies with small rodents. The instrumental tests which measure motor activity, neuromuscular functions, muscle stregth, emotionality and social behavior are also discussed. The usefulness of these procedures in toxicology is not yet established. Their introduction into the testing routine creates considerable logistic difficulties and might not be compatible with good laboratory practices. Therefore, it is suggested to explore the procedures developed by psychopharmalogists and behavioral scientists and to validate them with a variety of neurobehavioral toxins. Tests which produce relevant and reproducible data may then be added to the toxicological protocols, preferably within the framework of safety pharmacology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277811
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative analysis of rat activity in the home cage by infrared monitoring. Application to the acute toxicity testing of acetanilide and phenylmercuric acetate (1989)
    Springer
    Archives of toxicology 63 (1989), S. 85-96 
    Details
    ISSN: 1432-0738
    Keywords: Motor activity ; Toxicological screening ; Acetanilide ; Phenylmercuric acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new method for continuous in-cage monitoring of the activity of rats using passive sensors to detect the animals' infrared emissions, and its usefulness for toxicological screening tests is described. In order to obtain baseline values for toxicological tests, the differences between day and night activity, adaptation to changing day/night rhythm, the effects of handling the animals (measurement of body weight, food and water consumption) and the effect on activity patterns of the female estrus cycle were investigated. In two separate experiments, single doses of acetanilide and phenylmercuric acetate were administered. Passive infrared monitoring of motor activity proved to be a sensitive and discriminating method suitable for quantitative and qualitative assessment of acute toxic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316429
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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