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Embryotoxicity induced by alkylating agents (1983)

Platzek, T. ; Bochert, G. ; Rahm, U.

Springer

Archives of toxicology 52 (1983), S. 45-69

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ISSN: 1432-0738

Keywords: Acetoxymethyl-methylnitrosamine ; Teratogenicity ; NMRI mice ; Dose-response relationship ; DNA alkylation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Acetoxymethyl-methylnitrosamine, the acetate ester of the presumed reactive metabolite of dimethylnitrosamine, is an effective teratogen in NMRI mice. An unusual phenomenon of application route specificity and a pronounced phase specificity of the teratogenic effects induced are demonstrated. Dose-response relationships are established. Some further arguments are given to support the basic hypothesis that the teratogenicity of alkylating agents is closely correlated to the DNA alkylation rate of embryonic cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00317981

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