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  • Prions  (2)
  • Acetylcholine receptor  (1)
  • Amyotrophic lateral sclerosis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Transgenic and knockout mice in the study of neurodegenerative diseases (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 111-126 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Neurodegeneration ; Transgenic mouse ; Prions ; Spumavirinae ; Alzheimer's disease ; Anryotrophic lateral sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01575443
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Transgenic and knockout mice in the study of neurodegenerative diseases (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 111-126 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Key words Neurodegeneration ; Transgenic mouse ; Prions ; Spumavirinae ; Alzheimer’s disease ; Amyotrophic lateral sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer’s disease, and motor neuron diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01575443
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Excision of membrane patches reduces the mean open time of nicotinic acetylcholine receptors (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 385-392 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Acetylcholine receptor ; Membrane patch excision ; Channel kinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Excision of membrane patches from clonal BC3H1 cells to the inside-out configuration reduces the mean open time and burst duration of skeletal muscle nicotinic acetylcholine receptors. The channel conductance is not altered. Our results indicate that the rates for several steps in receptor activation are affected. The altered receptors apparently form a homogeneous population. Patterns of activity similar to that seen after excision are seen infrequently in recordings from cell-attached patches, suggesting that receptors with this type of altered function are present in intact membranes. The extent and rate of the reduction in mean open time after excision are similar at acetylcholine concentration over a 1000-fold range, indicating that the alteration does not depend on the state of ligation of the receptor. The extent and rate also are similar at room temperature and at 11° C. The changes seen indicate that careful comparisons to intact preparations are necessary when studying the gating of channels in excised patches or following reconstitution into artificial membranes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370744
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
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