ISSN:
1432-198X
Keywords:
Hemolytic uremic syndrome
;
Streptococcus pneumoniae
;
Jaundice
;
Hepatic injury
;
Asparagine transaminase
;
Alanine transaminase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Streptococcus pneumoniae is a uncommon etiological organism in hemolytic uremic syndrome (HUS). Production of neuraminidase byS. pneumoniae results in exposure of red blood cell T-antigen, resulting in hemolysis, thrombocytopenia, and acute renal failure. Hepatic involvement in this form of HUS has not been described in the literature. We report in three children withS. pneumoniae-associated HUS the presence of severely elevated transaminases and conjugated hyperbilirubinemia. Increases in asparagine transaminase ranged from 11 to 46 times normal values and an increase in alanine transaminase ranged from 1.6 to 8 times normal. In all patients the rise in total bilirubin was 7–15 times normal. Biliary tree obstruction and viral causes for liver dysfunction were absent. Hepatocellular injury inS. pneumoniae-associated HUS likely results from mechanisms involved in sepsis and pneumonia-induced jaundice, combined with severely increased bilirubin production following massive hemolysis. The hepatic injury in all three patients resolved within 9, 5, and 10 days. Our experience suggests that an extensive evaluation including liver biopsy is not indicated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00868713
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