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  • Achondrogenesis type I  (1)
  • Antibodies  (1)
  • Collagen fibrils  (1)
  • 1
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Plasmozytom ; Hoden ; Kristall ; Kristallbildung ; Antikörper ; Key words Plasmacytoma ; Testicle ; Crystal ; Crystal formation ; Antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary At the autopsy of a 68 year old man with plasmacytoma of the λ light chain type we found polygonal interstitial cells with unusual crystalline inclusions, which were not readily identifiable and slightly resembled Leydig cells in conventional microscopy. In electron microscopy these could be identified as plasmacytoma cells, representing a testicular involvement. Comparable cells could be shown in the bone marrow. In immunochemistry we found a polyclonal reaction for λ light chains suggesting a similar phenomenon as the so-called Russell bodies. As far as we know the literature, this finding in a testicular metastasis has not been described.
    Notes: Zusammenfassung Bei der Autopsie eines 68 jährigen Patienten mit einem Plasmozytom vom Leichtkettentyp λ fanden wir im Hodeninterstitium polygonale teils mehrkernige Zellen mit ungewöhnlichen kristallinen Einschlüssen, welche sich lichtoptisch nicht klar identifizieren ließen und entfernt an Leydig-Zellen erinnerten. Erst elektronenmikroskopisch konnten diese als Plasmozytomzellen, bei Vorliegen eines Hodenbefalls, identifiziert werden. Vergleichbare Zellen wurden auch im Knochenmark gefunden. Immunhistochemisch konnte eine polyklonale Immunoreaktivität für Leichtketten des Typs λ nachgewiesen werden, so daß ein den Russell-Körperchen ähnliches Phänomen angenommen werden muß. Unseres Wissens wurde ein solcher Befund bei einer Hodenmetastase noch nie beschrieben.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 134 (1980), S. 69-74 
    ISSN: 1432-1076
    Keywords: Achondrogenesis type I ; Ultrastructure ; Chondrocytes ; Cytoplasmic inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The light- and electron-microscopic structure of articular and costal cartilage in a case of achondrogenesis type I has been described. The most characteristic ultrastructural change in the chondrocytes was conspicuous dilatation of the rough endoplasmatic reticulum (RER) which contained amorphous electronopaque material. This change in the RER was accompanied by marked hypertrophy of the Golgi apparatus; the matrix was basically unchanged.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 4 (1986), S. 452-457 
    ISSN: 0736-0266
    Keywords: Spine ; Osteochondrosis ; Scheuermann's Disease ; Vertebra ; Electron microscopy ; Collagen fibers ; Collagen fibrils ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In osteochondrosis juvenilis Scheuermann, foci of various sizes in the cartilaginous end plates of the vertebral bodies display a loosening or complete interruption of the collagen fibers. These findings, together with an alteration and occasional absence of the growth zone, may result in the typical deformation of the vertebral bodies. Electron micrographs of the areas with optically absent collagen fibers reveal collagen fibrils. They are arranged in an irregular pattern. We conclude that a disturbance of collagen or ground substance biosynthesis is of importance in the pathogenesis of juvenile osteochondrosis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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