ISSN:
1432-0711
Keywords:
Paroxysmal noctural hemoglobinuria
;
Lactate dehydrogenase
;
α-hydroxybutyrate dehydrogenase
;
Pregnancy
;
Cerebral thrombosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In this report, the maternal and fetal risks in a patient with paroxysmal nocturnal hemoglobinuria (PNH) were evaluated. A patient with PNH carried a pregnancy to successful delivery, with a healthy male infant, and suffered from postpartum cerebral subcortical thrombosis followed by recovery. An elevated level of serum lactate dehydrogenase isoenzyme (α-hydroxybutyrate dehydrogenase) was observed during pregnancy; the level returned to normal by delivery. However, the hemoglobin concentration during pregnancy and post-partum was kept at 8 g/dl. This is the first report of a relation between the onset of hemolysis and pregnancy. The management of pregnancy in such patients is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00934129
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