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  • 1
    Electronic Resource
    Electronic Resource
    The effect of CO2 on monoamine metabolism in rat brain (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 301 (1977), S. 11-15 
    Details
    ISSN: 1432-1912
    Keywords: Hypercarbia ; Acidosis ; Monoamine metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary White male albino rats were exposed to artificial atmosphere containing 20% of O2 and 5, 10 and 15% of CO2, for periods of time ranging from 30 min to 2 h. Monoamine synthesis in different dissected brain areas was measured by estimating Dopa and 5-hydroxytryptophan (5-HTP) accumulation after inhibition of their decarboxylation with the L-aromatic aminoacid decarboxylase inhibitor NSD 1015 (3-hydroxybenzylhydrazine). Endogenous levels of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), and NA and DA levels after inhibition of catecholamine synthesis with α-methyltyrosine (α-MT) were measured in dissected areas and whole brain. The synthesis of all three monoamines was found to be increased in all the cerebral regions. Endogenous dopamine levels with or without α-MT treatment were increased while NA levels decreased. 5-HT decreased in at least one area and 5-HIAA increased in several brain areas. These observations indicate that the utilization of NA and 5-HT is increased and that of DA is diminished in acidosis, presumably as a consequence of a corresponding change in nerve impulse flow. The similarity between the monoamine changes induced by hypercarbia and by GABA are pointed out. It is suggested that GABA-ergic activity is elevated in acidosis and that GABA may be involved in the pH dependence of seizure thresholds, as well as in the increased tendency to respiratory depression induced by central nervous system depressant drugs in patients with chronic respiratory failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501258
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  • 2
    Electronic Resource
    Electronic Resource
    Crystallization behaviour of polyoxetanes: poly(oxetane), poly (3,3-dimethyloxetane) and poly(3,3-diethyloxetane) (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 571-576 
    Details
    ISSN: 1435-1536
    Keywords: Poly(oxetane) ; poly(3,3-dimethyloxetane) ; poly(3,3-diethyloxetane) ; crystallization behaviour ; DSC curves ; X-ray diagrams
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The influence of the crystallization temperature on the melting behaviour and crystalline structure of polyoxetane (PTO), poly(3,3-dimethyloxetane) (PDMO) and poly(3,3-diethyloxetane) (PDEO) has been studied using differential scanning calorimetry (DSC) and X-ray techniques. When PTO is crystallized by cooling from the relaxed melt state, only the orthorhombic modification is obtained. However, PDMO and PDEO can be crystallized in two different modifications depending on crystallization temperature. The effect of the substituents in the stability of main chain conformations in crystalline state is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526622
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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