ISSN:
1432-1459
Keywords:
Ceruletide
;
Cholecystokinin
;
Thalamic tremor
;
Action tremor
;
Posteroventral lateral nucleus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two men, aged 63 and 71 years, developed a gross action tremor and dysesthesias several months after an intracerebral hemorrhage. CT and MRI showed a small hemorrhage in the posterior region of the lateral nucleus of the thalamus in each patient. The tremor occurred on movement, had frequencies of 2.5-4.5 Hz and the amplitude varied depending on the joint position of the limb. Ceruletide (a cholecystokinin analog) 0.8 μg/kg i.m. produced a marked reduction in the action tremor and improved motor function. This effect appeared 10 15 min after the injection, and lasted for up to 4 weeks. It is suggested that ceruletide may be of value in the treatment of action tremors following a thalamic lesion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00857518
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