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  • 1
    ISSN: 1432-0738
    Keywords: Key words Atractylon(Atr) ; tert-Butyl hydroperoxide (t-BHP) ; Lipid peroxidation ; Hepatotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Atractylon, a main sesquiterpenic constituent of Atractylodes rhizomes, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in primary culture of rat hepatocytes. In the preliminary study, atractylon showed an effective antioxidant property tested by its capacity for quenching 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). Further investigations showed that atractylon at the concentrations of 0.01, 0.1 and 1.0 mg/ml decreased the formation of malondialdehyde (MDA), leakage of lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) and repair synthesis of DNA induced by 30-min treatment of t-BHP (1.5 mM) in primary cultured rat hepatocytes. Addition of atractylon also attenuated the genotoxicity of t-BHP evaluated by unscheduled DNA synthesis. The sum of the results suggested that the protective effect of atractylon against oxidative stress induced by t-BHP is via its ability to quench free radicals.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Real-time systems 11 (1996), S. 289-302 
    ISSN: 1573-1383
    Keywords: Active Noise Control ; Genetic Algorithm ; FIR Filtering ; Parallel Real-Time Architecture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract A modified model, in the form of an FIR filter, is proposed for the modelling of the acoustic dynamics of an active noise control system. This is a low order filter formulation but consists of two independent elements—a time delay and a d.c. gain. Empirical data has shown that this model constitutes a good representation of the equivalent high order FIR filter and has the additional feature of being a high frequency noise filtering device. Because of its specific structure, the time delay and gain must be identified independently. This restricts the use of the conventional least mean squares technique for parameter optimization, as the cost function intrinsically comprises multimodal error surfaces. The use of Genetic Algorithms could be the best solution to address this issue but their unpredictable response in real-time require some special attention. A fully developed active noise control system, based on the Genetic Algorithm, to achieve the objective of noise reduction is described. To further guarantee the reliability of this approach, a supervisory scheme is incorporated for governing the real-time learning operations. A parallel hardware architecture, using two independent TMS320C30 digital signal processors, is designed for such implementation. The experimental results indicate that this approach to noise control is sound, and that noise reduction of more than 15dB(A) is consistently obtained.
    Type of Medium: Electronic Resource
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