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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 13 (1999), S. 196-200 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Migräne ; Akupunktur ; Alternative Therapiemethoden ; Diagnostik ; Entspannungsverfahren ; Psychotherapie ; Key words Migraine ; Acupuncture ; Paramedical treatment methods ; Diagnostic features ; Relaxation methods ; Psychotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: Migraine is a common neurological disorder (16% women, 6% men) associated with high direct and indirect costs. We evaluated the diagnostic and paramedical therapeutic measures by estimating the expenditure per patient and the effect of treatment. Methods: A questionnaire was sent to 1000 patients attending the Essen outpatient headache centre in 1995. A total of 293 patients responded, of whom 165 were eligible and could be evaluated. Patients were asked to report diagnostic tests, paramedical treatments applied, average duration of success (defined as meaningfuly reduction in migraine frequency) and costs of paramedical therapy. Results: Paramedical methods of therapy most frequently used were acupuncture, special pads, relaxation methods and herbal therapy. A total of 579 (3.5 on average) diagnostic procedures such as brain or cervical spine CT and MRI or EEG was performed. The average cost for acupuncture was $ 465, while the success was maintained for 3.2 months. $ 1510 was spent on psychotherapy, which was successful for 1.7 months. Patients spent $ 93 for relaxation methods, achieving migraine relief for 7.4 months. Conclusion: Paramedical treatments lack scientific proof, while both acute and prophylactic treatment strategies have been successfully tested in many clinical trials. Paramedical treatment shows a good temporally effect in individual patients.
    Notes: Zusammenfassung Einleitung: Migräne ist eine weit verbreitete (16% aller Frauen, 6% aller Männer) neurologische Erkrankung, die hohe direkte und indirekte Kosten verursacht. Methode: Ziel der Studie war, mittels eines Fragebogens, der an 1000 Patienten, die 1995 die Kopfschmerzambulanz der Uniklinik Essen aufsuchten, verschickt wurde, Auskunft über durchgeführte alternative Therapieverfahren, den damit für die Patienten entstandenen Kosten und den Nutzen (definiert als subjektive Reduktion des Schmerzes oder der Attackenfrequenz) zu erhalten. Weiterhin wurde nach durchgeführten apparativen diagnostischen Verfahren gefragt. Ergebnisse: Die am häufigsten genutzten alternativen Therapieverfahren waren Akupunktur, Lagerungshilfsmittel, Entspannungsverfahren und heilpflanzliche Präparate. 579 diagnostische Verfahren (durchschnittlich 3,5 pro Patient) wie CT und MRT des Kopfs oder EEG wurden durchgeführt. Die durchschnittlichen Kosten für Akupunktur betrugen 791  DM. Der von den Patienten angegebene Erfolg lag hier bei 3,2 Monaten. 2567  DM wurden für Psychotherapie ausgegeben. Die Patienten profitierten lediglich 1,7 Monate von dieser Therapieform. Das Ergebnis zeigt weiterhin, daß die Entspannungsverfahren die beste Kosten-Nutzen-Relation aufweisen (185  DM/7,2 Monate). Schlußfolgerung: Außer für das Muskelrelaxationsverfahren nach Jacobson als Entspannungsverfahren gibt es keinen wissenschaftlichen Nachweis für die Wirksamkeit von alternativen Therapiestrategien. Einzelne Patienten berichten jedoch temporär über Erfolge von alternativen Therapiemöglichkeiten. Die Wirksamkeit schulmedizinischer medikamentöser Verfahren ist durch wissenschaftliche Untersuchungen gut belegt, und die Patienten profitieren bei richtiger Anwendung der Therapieempfehlungen von diesen. Auch für alternative Therapieverfahren muß der wissenschafliche Nachweis der Wirksamkeit gefordert werden.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD.
    Type of Medium: Electronic Resource
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