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  • 1
    Electronic Resource
    Electronic Resource
    The CSF-protein pattern in acute cerebellar ataxia of childhood and intracranial midline tumours (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 49-57 
    Details
    ISSN: 1432-1076
    Keywords: Cerebrospinal fluid ; Protein electrophoresis ; Acute cerebellar ataxia ; Medulloblastoma ; Astrocytoma ; Pontine glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CSF-protein profiles of 25 children with acute cerebellar ataxia and of 39 children with intracranial midline tumours at diagnosis were examined by quantitative zone electrophoresis in agarose gel. The profiles were compared with those obtained from a control group of 86 cases, and those from 61 patients with aseptic meningitis and 40 children with bacterial meningitis. The data from the latter groups demonstrated the CSF-protein pattern of moderate or severe disturbance of the blood-CSF barrier (B-CSF-B), respectively. The children with acute cerebellar ataxia showed minor signs of a B-CSF-B impairment and no increase of γ-globulin. These findings point to a slight acute vascular lesion. CSF changes indicative of a moderate-to-severe dysfunction of the B-CSF-B occurred in the majority of the patients with cerebellar astrocytomas, pontine gliomas, tumours around the 3rd ventricle, and medulloblastomas. Therefore acute cerebellar ataxia can be differentiated from intracranial midline tumours in most cases by means of CSF-protein electrophoresis. A striking finding was that 12 out of 14 children with medulloblastomas revealed a marked increase of γ-globulin. Since in 5 of these cases oligoclonal γ-globulin could be detected, this finding means local immunoglobulin synthesis within the CNS. The marked increase of γ-globulin which almost exclusively occurred in association with medullo-blastomas allows their seperation from acute cerebellar ataxia and the other tumour groups. Quantitative agarose gel electrophoresis can be a complementary diagnostic test in children with acute ataxia and suspected of having a CNS infection, or in cases with a negative CT brain scan in which intracranial midline tumour is a likely possibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441170
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  • 2
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Wirkung von Carbamazepin auf die neurosekretorischen Kerne der Ratte (1970)
    Springer
    Clinical and experimental medicine 153 (1970), S. 95-98 
    Details
    ISSN: 1591-9528
    Keywords: Neurosecretion ; Carbamazepine ; Histochemistry ; Neurosekretion ; Carbamazepin ; Histochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Enzyme TPP, NADPH2-D, G6PDH und sPh ließen sich bei Ratten im osmotischen Streß in erhöhter Aktivität nachweisen. Längerer Wasserentzug führte bei den Tieren zu einem fast völligen Schwinden des Neurosekretes. Die Gabe von Carbamazepin hatte weder einen Einfluß auf die Enzymaktivitäten noch auf die Neurosekretproduktion. Die Befunde sprechen dagegen, daß Carbamazepin am Bildungsort des ADH wirksam wird.
    Notes: Summary Due to an osmotic stress rats showed an increased activity of the enzymes thiaminphosphatase, acid phosphatase, NADPH2-diaphorase and glucose-6-phosphat-dehydrogenase in their neurosecretory nuclei. Carbamazepine did not influence these enzyme activities neither in thursting rats nor in those fed regularly. Its antidiuretic effect can therefore not he explained by stimulation of the nucleus supraopticus or paraventricularis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048197
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    Paper (German National Licenses)
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