ISSN:
1432-1440
Keywords:
Acute lymphoblastic leukaemia in children
;
Therapy
;
Coagulation factors
;
Proteinase inhibitors
;
Fibronectin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The thrombocyte count, the factor XIII (F XIII) activity, the concentration of fibrinogen (F I), prothrombin (F II), fibronectin (CIG), albumin and the proteinase inhibitors antithrombin III (AT III), alpha 2-macroglobulin (A2M), alpha 1-antitrypsin (A1A) and Cl-esterase inactivator (C $$\bar 1$$ -INA) were determined in ten children with acute lymphoblastic leukaemia (ALL). Changes due to the disease and to therapy were observed. Before the start of treatment the patients had thrombocytopenia secondary to the disease, and the proteinase inhibitors — especially C $$\bar 1$$ -INA and A1A — were raised. During the induction phase the thrombocyte count rose but there was also a marked increase in the concentration of F II and CIG. During the consolidation phase there was a general fall in protein concentration underl-asparaginase medication. The cause was attributed to a disorder of protein synthesis. The concentration of the factors studied rose again during maintenance therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01712183
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