ISSN:
1432-1076
Keywords:
Pyoderma gangrenosum
;
Acute myeloid leukaemia
;
6-Mercaptopurine
;
Methotrexate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We describe a patient who developed pyoderma gangrenosum during the remission phase of acute myeloid leukaemia whilst receiving maintenance therapy with methotrexate and 6-mercaptopurine. The spontaneous resolution of these skin lesions following discontinuation of chemotherapy suggests that these drugs may be of major significance in the aetiology of pyoderma gangrenosum. Nevertheless, 27 months later, a relapse of the leukaemia followed. Although pyoderma gangrenosum occurred during clinical remission, we cannot rule out a synergism of leukaemia and chemotherapy in its pathogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441810
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