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  • Acute renal failure  (1)
  • Benzoates  (1)
  • Colorado dams  (1)
  • Dog kidney  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 1 (1987), S. 348-358 
    ISSN: 1432-198X
    Keywords: Acute renal failure ; Glomerular ultrafiltration ; Tubular injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute renal failure (ARF) is a common clinical entity which results from multiple causes. Experimental models in animals have duplicated many of the clinical syndromes which can be classified into (1) ARF due to increased filtered load of endogenous and exogenous materials, (2) ARF associated with exogenous nephrotoxins and (3) ischemic forms of renal failure secondary to hypoperfusion and hypotension. The mechanisms leading to the reduction in GFR are multiple and the alterations in determinants of nephron filtration rate and degree of tubular backleak and obstruction are described for each of these subtypes of experimental ARF. The specific mechanisms whereby tubular damage translates into a reduction in GFR in ARF are discussed for each sub-type of ARF. Tubular damage can often be dissociated from the reduction in GFR, possibly by inhibiting tubuloglomerular feedback responses, but such increases in GFR and nephron filtration rate are not necessarily beneficial to the organism because of potential volume depletion and the risk of magnifying further tubular damage. Information on the physiologic role of tubuloglomerular feedback activity in ARF is provided and supports the concept that feedback induced reductions in GFR after tubular injury may preserve extracellular volume and minimize further tubular damage. Reductions in tubular metabolic work appears to prevent and ameliorate further tubular injury after the initial insult. The mechanisms which associate changes in GFR and tubular damage can now be described, and therapies which improve GFR without correcting the tubular damage may compound the clinical problem and increase renal damage.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 102-107 
    ISSN: 1432-1912
    Keywords: p-Aminohippurate ; Benzoates ; Isolated membrane vesicles ; Organic anion transport ; Dog kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of substituted benzoates on the transport of p-aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV) isolated from dog kidney cortex. For both membranes, kinetic analysis of [3H]PAH transport in the presence of a fixed concentration of two different benzoates, respectively, revealed an increase in the apparent K m, for PAH, while the transport capacity (V max) was unaffected. This is compatible with competitive inhibition of a common transport pathway. A range of 19 monosubstituted benzoates were then tested as potential inhibitors by measuring the probenecid-sensitive fraction of 100 μmol/l PAH uptake into BLMV and BBMV in the presence of 5 mmol/l benzoate, and apparent inhibition constants (K j) were calculated. For all benzoates the inhibitory potency in BBMV was lower than in BLMV, but the pattern of inhibition was similar; the most pronounced inhibition was found for 3-Cl- and 4-Cl-benzoate, while the least pronounced inhibition was found for the 3-NH2 and 4-NH2 substitutes. The inhibitory potency, expressed as logK i, correlated significantly with the relative hydrophobicity of the benzoates determined by reversed phase HPLC, whereas a poor correlation was found between pKa and logK i. This indicates that hydrophobic and electronic parameters are the main determinants of affinity for the PAH transport system. It is suggested that the PAH transport system present in the proximal tubules is responsible for the active secretion of benzoates by the mammalian kidney.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Natural hazards 14 (1996), S. 227-240 
    ISSN: 1573-0840
    Keywords: Colorado dams ; earthquake recurrence ; probabilistic distances ; probabilistic seismic hazard analysis ; peak horizontal acceleration ; acceleration response spectra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A seismic hazard evaluation for three dams in the Rocky Mountains of northern Colorado is based on a study of the historical seismicity. To model earthquake occurrence as a random process utilizing a maximum likelihood method, the catalog must exhibit random space-time characteristics. This was achieved using a declustering procedure and correction for completeness of recording. On the basis of the resulting a- and b-values, probabilistic epicentral distances for a 2 × 10−5 annual probability were calculated. For a random earthquake of magnitude M L 6.0–6.5, this distance is 15 km. Suggested ground motion parameters were estimated using a probabilistic seismic hazard analysis. Critical peak horizontal accelerations at the dams are 0.22g if median values are assumed and 0.39g if variable attenuation and seismicity rates are taken into account. For structural analysis of the dams, synthetic acceleration time series were calculated to match the empirical response spectra. In addition, existing horizontal strong motion records from two Mammoth Lakes, California earthquakes were selected and scaled to fit the target horizontal acceleration response spectra.
    Type of Medium: Electronic Resource
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