ISSN:
1432-2013
Keywords:
Acute renal failure
;
Tubuloglomerular feedback
;
Renin-angiotensin system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary It has been previously demonstrated that single nephron filtration rate, whole kidney glomerular filtration rate and total renal blood flow decreased by 30–35% 6 h after uranyl nitrate induced acute renal failure in the rat. In order to evaluate a role of the renin-angiotensin system in the initiating phase (0–6 h) of this model of acute renal failure, determinations of plasma renin activity, superficial (S) and deep (D) juxtaglomerular apparatus (JGA) renin activity and distal nephron [Na+] were obtained. Plasma renin activity increased from the control value of 1.5±0.3 (S.E.M.) to 2.9±0.4 ng/ml/h (P〈0.005) at 6 h. Mean renin activity in S- and D-JGA's of control rats was 6.99±0.41 and 2.67±0.21 ng/JGA/h, respectively. After uranyl nitrate, renin activity in S-JGA's increased to 13.62±0.80 ng/JGA/h (P〈0.001) at 2 h and remained elevated, 12.56±0.90 and 12.75±0.87 ng/JGA/h at 4 and 6 h. D-JGA renin activity increased (P〈0.05) to 7.04±0.53, 6.23±0.31 and 3.44±0.33 ng/JGA/h at 2, 4 and 6 h after uranyl nitrate. Distal tubule [Na+], 27 samples in 6 rats, increased from a mean control value of 53.7±1.2 mEq/l to 116.9±2.5 mEq/1, 24 samples in 6 rats (P〈0.001). Prompt increases in JGA renin activity were observed in the initiating phase of acute renal failure, suggesting a role for the renin-angiotensin system in the pathophysiology of this nephrotoxic model. The association of increased JGA renin activity and increased distal [Na+] is consistent with a role for the tubuloglomerular feedback mechanism in the initiating phase of uranyl nitrate induced acute renal failure in the rat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581757
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