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  • 1
    Electronic Resource
    Electronic Resource
    Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive Care (1997)
    Springer
    Intensive care medicine 23 (1997), S. 1204-1211 
    Details
    ISSN: 1432-1238
    Keywords: Key words Severity of illness ; Patient outcome assessment ; haemofiltration ; Acute renal failure ; Epidemiology ; Mortality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the epidemiology of acute renal failure (ARF) and to identify predictors of mortality in patients treated by continuous venovenous haemodiafiltration (CVVHDF). Design: Uncontrolled observational study. Setting: One intensive care unit (ICU) at a surgical and trauma centre. Patients: A consecutive sample of 3591 ICU treatments. Measurements and results: Demographic data, indications for ICU admission, severity scores and organ system failure at the beginning of CVVHDF were set against the occurrence of ARF and ICU mortality. 154 (4.3 % of ICU patients and 0.6 % of the hospital population) developed ARF and were treated with CVVHDF. Higher American Society of Anesthesiologists (ASA) status and higher Apache II score were associated with ICU incidence of ARF. However, these criteria were not able to predict outcome in ARF. A simplified predictive model was derived using multivariate logistic regression modelling. The mortality rates were 12 % with one failing organ system (OSF), 38 % with two OSF, 72 % with three OSF, 90 % with four OSF and 100 % with five OSF. The adjusted odds ratio (OR) of death was 7.7 for cardiovascular failure, 6.3 for hepatic failure, 3.6 for respiratory failure, 3.0 for neurologic failure, 5.3 for massive transfusion and 3.7 for age of 60 years or more. Conclusion: General measures of severity are not useful in predicting the outcome of ARF. Only the nature and number of dysfunctioning organ systems and massive transfusion at the beginning of CVVHDF and the age of the patients gave a reliable prognosis in this group of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050487
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  • 2
    Electronic Resource
    Electronic Resource
    Therapie und Prophylaxe bei MRSA-Infektionen auf Intensivstationen (1999)
    Springer
    Intensivmedizin und Notfallmedizin 36 (1999), S. 612-618 
    Details
    ISSN: 1435-1420
    Keywords: Key words MRSA ; Synercid ; VRSA ; Decontamination ; Schlüsselwörter MRSA ; Synercid ; VRSA ; Dekontamination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diese Übersichtsarbeit zeigt den aktuellen Stand der Behandlung und Prophylaxe bei Infektion mit Methicillin-resistenten Staphylococcus-aureus-Stämmen (MRSA) und den seit kurzem aufgetretenen Vancomycin-resistenten Staphylokokken (VRSA) unter besonderer Berücksichtigung intensivmedizinischer Probleme. Dargestellt werden die hygienischen bzw. Isolationsmaßnahmen, welche zum Behandlungskonzept einer MRSA-Infektion im Zuge einer Krankenhausepidemie gehören, wie auch die chemotherapeutischen Möglichkeiten in der Therapie einer MRSA-Infektion sowohl lokal als auch systemisch, unter besonderer Berücksichtigung der kurz vor ihrer europaweiten Einführung stehenden Substanz Quinupristin/ Dalfopristin (Synercid, Rhone-Poulenc RP 59500) und deren Wirkungsspektrum bei VRSA- und MRSA-Infektion.
    Notes: Summary The review shows the development in the prophylactics and therapy of methicillin (multi)-resistant Staphylococcus aureus (MRSA) and the lately emergenced vancomycin-resistant Staphylococcus aureus (VRSA) strains the lately emergenced. A state of the art decontamination and isolation guideline with a special emphasis on critical care patients is given. Also the article reviews the currently used antibiotic drugs for local and systemic treatment of MRSA infection. The most important systemic administered drugs are discussed with a focus on glycopeptides. Quinupristin/ Dalfopristin (Synercid®, RP 59500) as a substance, which is currently being clinically investigated and is close to its registration, is also introduced and quoted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003900050352
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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