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  • Adaptation  (1)
  • Colon cancer screening  (1)
  • Desirability index  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Single-visit screening and treatment of first-degree relatives (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 1120-1124 
    Details
    ISSN: 1530-0358
    Keywords: Colon cancer screening ; Radiology colonoscopy ; Sigmoidoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A pilot study has been carried out to evaluate three aspects of screening of first-degree relatives of patients with colon cancer in four Hamilton hospitals; yield of adenomas, feasibility of a one-visit approach to screening and treatment, and compliance. Protocol included flexible sigmoidoscopy after full bowel preparation, followed immediately by either therapeutic colonoscopy or diagnostic barium enema, depending on the flexible sigmoidoscopy findings. We found adenomas in 19 percent of 88 first-degree relatives, with a mean age of 52, compared with an expectation of 8 percent. The protocol was found to be acceptable to the relatives and workable for the various groups of physicians in three of four hospitals, despite many initial logistic difficulties. Numerous problems were encountered with compliance of referring physicians, index patients, relatives, and investigating physicians.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050075
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The area under the function: an index for selecting desirable genotypes (1993)
    Springer
    Theoretical and applied genetics 87 (1993), S. 409-415 
    Details
    ISSN: 1432-2242
    Keywords: Genotype x environment interaction ; Adaptation ; Stability ; Desirability index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The linear regression approach has been widely used for selecting high-yielding and stable genotypes targeted to several environments. The genotype mean yield and the regression coefficient of a genotype's performance on an index of environmental productivity are the two main stability parameters. Using both can often complicate the breeder's decision when comparing high-yielding, less-stable genotypes with low-yielding, stable genotypes. This study proposes to combine the mean yield and regression coefficient into a unified desirability index (D i). Thus, D i is defined as the area under the linear regression function divided by the difference between the two extreme environmental indexes. D i is equal to the mean of the i th genotype across all environments plus its slope multiplied by the mean of the environmental indexes of the two extreme environments (symmetry). Desirable genotypes are those with a large D i. For symmetric trials the desirability index depends largely on the mean yield of the genotype and for asymmetric trials the slope has an important influence on the desirability index. The use of D i was illustrated by a 20-environments maize yield trial and a 25-environments wheat yield trial. Three maize genotypes out of nine showed values of D i 's that were significantly larger than a hypothetical, stable genotype. These were considered desirable, even though two of them had slopes significantly greater than 1.0. The results obtained from ranking wheat genotypes on mean yield differ from a ranking based on D i .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215085
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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