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Digitale Medien

Effects of Nucleus on Leukocyte Recovery (1999)

Kan, Heng-Chuan ; Shyy, Wei ; Udaykumar, H. S. ; [weitere]

Springer

Annals of biomedical engineering 27 (1999), S. 648-655

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ISSN: 1573-9686

Schlagwort(e): Leukocyte model ; Computational cellular dynamics ; Cell recovery

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin , Technik allgemein

Notizen: Abstract The rheological properties of a leukocyte significantly affect its biological and mechanical characteristics. To date, existing physical models of leukocyte are not capable of quantitatively explaining the wide range of deformation and recovery behaviors observed in experiment. However, a compound drop model has gained some success. In the present work, we investigate the effect of nucleus size and position, and the relative rheological properties of cytoplasm and nucleus, on cell recovery dynamics. Two nucleus sizes corresponding to that of neutrophil and lymphocyte are considered. Direct comparison between numerical simulations and experimental observation is made. Results indicate that the time scale ratio between the nucleus and cytoplasm plays an important role in cell recovery characteristics. Comparable time scales between the two cell components yield favorable agreement in recovery rates between numerical and experimental observations; disparate time scales, on the other hand, result in recovery behavior and cell shapes inconsistent with experiments. Furthermore, it is found that the nucleus eccentricity exhibits minimum influence on all major aspects of the cell recovery characteristics. The present work offers additional evidence in support of the compound cell model for predicting the rheological behavior of leukocytes. © 1999 Biomedical Engineering Society. PAC99: 8717-d, 8719Tt

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1114/1.214

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Digitale Medien

Computation of complex fluid flows using an adaptive grid method (1988)

Shyy, Wei

Chichester : Wiley-Blackwell

International Journal for Numerical Methods in Fluids 8 (1988), S. 475-489

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ISSN: 0271-2091

Schlagwort(e): Adaptive grid computation ; High Reynolds number flow ; Engineering ; Engineering General

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Maschinenbau

Notizen: Recently the concept of adaptive grid computation has received much attention in the computational fluid dynamics research community. This paper continues the previous efforts of multiple one-dimensional procedures in developing and asessing the ideas of adaptive grid computation. The focus points here are the issue of numerical stability induced by the grid distribution and the accuracy comparison with previously reported work. Two two-dimensional problems with complicated characteristics - namely, flow in a channel with a sudden expansion and natural convection in an enclosed square cavity - are used to demonstrate some salient features of the adaptive grid method. For the channel flow, by appropriate distribution of the grid points the numerical algorithm can more effectively dampen out the instabilities, especially those related to artificial boundary treatments, and hence can converge to a steady-state solution more rapidly. For a more accurate finite difference operator, which contains less undesirable numerical diffusion, the present adaptive grid method can yield a steady-state and convergent solution, while uniform grids produce non-convergent and numerically oscillating solutions. Furthermore, the grid distribution resulting from the adaptive procedure is very responsive to the different characteristics of laminar and turbulent flows. For the problem of natural convection, a combination of a multiple one-dimensional adaptive procedure and a variational formulation is found very useful. Comparisons of the solutions on uniform and adaptive grids with the reported benchmark calculations demonstrate the important role that the adaptive grid computation can play in resolving complicated flow characteristics.

Zusätzliches Material: 13 Ill.