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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Lasers in medical science 1 (1986), S. 75-80 
    ISSN: 1435-604X
    Keywords: Neodymium-YAG laser ; colorectal cancer ; Photocoagulation ; Obstruction ; Bleeding ; Adenocarcinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The merits of the Nd-YAG laser were evaluated in palliation of obstruction, or bleeding, or both, in 84 patients with colorectal malignancy. Luminal patency was restored in 20 of the 24 patients with obstructing colonic cancers. Haemostasis was achieved in 37 of the 40 patients with bleeding. Combined bleeding and obstruction responded favourably in 19 of the 20 patients treated. Only a few laser photocoagulation sessions, over a short period of time, were needed, and further laser treatment could be continued on an outpatient basis. Major complications such as perforation (6), stenosis necessitating a colostomy (3), and delayed post-treatment bleeding (2) were seen in 13% of patients, with a laser-related mortality in three patients. Minor complications, such as transient stenosis (22) and laser-induced bleeding (11), responded well to further laser application. Pain and warmth (20) resolved spontaneously. Treatment failures and complications were mainly due to inadequate accessibility or were related to tissue characteristics. Laser photocoagulation appears to constitute a valuable alternative treatment, not only to resection and colostomy, in the case of obstruction, but also for haemorrhage that cannot be controlled in other ways. Palliation, in its broad sense, is guaranteed because of the rapid results, reduced time in hospital, the avoidance of hospital admission, and the good tolerance of treatment.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 11 (1989), S. 20-22 
    ISSN: 1573-739X
    Keywords: Beclomethasone ; Chromatography, high pressure liquid ; Chromatography, thin layer ; Drug compounding ; Drug stability ; Enema ; Mesalazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A beclomethasone dipropionate (BDP) enema and a BDP/mesalazine combination enema (containing 2 mg BDP and 1 g mesalazine and 2 mg BDP, respectively per 40 ml) were formulated. BDP and mesalazine were suspended in a carbomer-water gel. No degradation of BDP was measured during the storage period of the BDP enema (4 weeks at 20°C) and of the BDP/mesalazine enema (44 days at 4°C, 20°C and 37°C, respectively). Progressive darkening of colour occurred for the BDP/mesalazine enema during storage at 20°C and at 37°C, probably induced by mesalazine degradation products. Only very slight colouring was observed at 4°C. Hardly any precipitation of BDP and mesalazine was seen during the storage period and the enemas could easily be resuspended.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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