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  • Adenosine 5′-triphosphate  (1)
  • Key words: Synchrotron – Iodine – Gadolinium – CT – Brain – Glioma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Feasibility of synchrotron radiation computed tomography on rats bearing glioma after iodine or gadolinium injection (2000)
    Springer
    European radiology 10 (2000), S. 1487-1492 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Synchrotron – Iodine – Gadolinium – CT – Brain – Glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this work was to demonstrate the feasibility of a new imaging technique called synchrotron radiation computed tomography (SRCT). This technique leads to a direct assessment of the in vivo concentration of an iodine- or gadolinium-labeled compound. Rats bearing C6 glioma were imaged by MRI prior to the SRCT experiment. The SRCT experiments were performed after a 1.3 g I/kg (n = 5) or a 0.4 g Gd/kg (n = 5) injection. Finally, brains were sampled for histology. The SRCT images exhibited contrast enhancement at the tumor location. Ten minutes after injection, iodine and gadolinium tissular concentrations were equal to 0.80 ( ± 0.40) mg/cm3 and 0.50 ( ± 0.10) mg/cm3, respectively in the peripheral area of the tumor (respective background value: 0.20 ± 0.02 to 0.10 ± 0.01). Correlation to MRI and histology revealed that the contrast uptake occurred in the most vascularized area of the tumor. The present study summarizes the feasibility of in vivo SRCT to obtain quantitative information about iodine and gadolinium-labeled compounds. Beyond brain tumor pathology, the SRCT appears as a complementary approach to MRI and CT, for studying iodine- and gadolinium-labeled compounds by the direct achievement of the tissular concentration value in the tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300000509
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  • 2
    Electronic Resource
    Electronic Resource
    Standardisation of 31phosphorus-nuclear magnetic resonance spectroscopy determinations of high energy phosphates in humans (1994)
    Springer
    European journal of applied physiology 68 (1994), S. 107-110 
    Details
    ISSN: 1439-6327
    Keywords: Adenosine 5′-triphosphate ; Phosphocreatine ; Age ; Training status ; Method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A procedure is described for standardising the determination of adenosine 5′-triphosphate and phosphocreatine concentration ([ATP] and [PC], respectively, in absolute arbitrary units) in human muscle by nuclear magnetic resonance (NMR) spectroscopy. The individual 31phosphorus (21P)-NMR spectra obtained on equal hemispherical tissue volumes (muscle plus skin and fat) were corrected for the thickness of the skin and of the subcutaneous fat. The volumes investigated were standardised using an external reference. The procedure described made possible the comparison of high energy phosphate concentrations among different subjects. It was applied to the assessment of [ATP] and [PC] in four groups of sedentary subjects (children, and adults aged 20–35, 35–50 and over 50 years), and in a group of athletes (volleyball players). The [ATP] and [PC] were not statistically different in the groups investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00244021
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    Paper (German National Licenses)
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